Molecular structure of Clofarabine, CAS Number: 123318-82-1
Clofarabine (CAS 123318-82-1)
Alternate Names:
(2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol 2-chloro-2′′-arabino-fluoro-2′′-deoxyadenosine
Application:
Clofarabine is a ribonucleotide reductase and DNA polymerase inhibitor
CAS Number:
123318-82-1
Purity:
≥99%
Molecular Weight:
303.7
Molecular Formula:
C10H11ClFN5O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Clofarabine is a purine nucleoside analogue that is a lipophilic derivative of 2-Chloro-2'-deoxyadenosine (sc-202399). The advantage to using this compound compared to 2-Chloro-2'-deoxyadenosine is the increased stability of the acid. Studies suggest that Clofarabine contains the best qualities of Fludarabine (sc-204755) and 2-Chloro-2'-deoxyadenosine, with increased resistance to deamination and phosphorolysis. The compound functions by inhibiting intracellular ribonucleotide reductase and DNA polymerase, which suppresses DNA replication. Furthermore, Clofarabine displays greater affinity towards dCK (deoxycytidine kinase, dCyd), an enzyme essential in nucleoside phosphorylation.
Clofarabine (CAS 123318-82-1) References
- The distribution, metabolism, and elimination of clofarabine in rats. | Bonate, PL., et al. 2005. Drug Metab Dispos. 33: 739-48. PMID: 15743978
- Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine. | Seedhouse, C., et al. 2009. Clin Cancer Res. 15: 7291-8. PMID: 19934300
- Renal excretion of clofarabine: assessment of dose-linearity and role of renal transport systems on drug excretion. | Ajavon, AD., et al. 2010. Eur J Pharm Sci. 40: 209-16. PMID: 20347037
- Clofarabine in leukemia. | Ghanem, H., et al. 2010. Expert Rev Hematol. 3: 15-22. PMID: 21082931
- Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. | Yamauchi, T., et al. 2014. Anticancer Res. 34: 1657-62. PMID: 24692694
- Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase. | Yamanishi, M., et al. 2015. Exp Hematol. 43: 207-14. PMID: 25461250
- The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia. | Stumpel, DJ., et al. 2015. Eur J Cancer. 51: 2008-21. PMID: 26188848
- Clofarabine Has Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene Expression. | Rahmati-Yamchi, M., et al. 2015. Adv Pharm Bull. 5: 471-6. PMID: 26819918
- Dosing-time contributes to chronotoxicity of clofarabine in mice via means other than pharmacokinetics. | Luan, JJ., et al. 2016. Kaohsiung J Med Sci. 32: 227-34. PMID: 27316580
- Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine. | Goss, KL., et al. 2017. Oncotarget. 8: 87016-87032. PMID: 29152060
- Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis. | Long, MJC., et al. 2020. Cell Chem Biol. 27: 122-133.e5. PMID: 31836351
- Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells. | Sevim, H., et al. 2021. PLoS One. 16: e0253170. PMID: 34133426
- Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters. | Miller, SR., et al. 2021. Pharmacol Res Perspect. 9: e00831. PMID: 34288585
Inhibitor of:
ADAT3, AMDHD2, APRT, Atase, CTP, CTPS, dCK, DERA, DGUOK, DNA pol α, DNA pol β, dNT-1, DTYMK, GMPPB, GMPR1, GMPR2, GUCD1, GUK1, ISYNA1, LOC644196, NASP, Nucleoside Monophosphate Kinase, NUDT16L1, PIG-YL, PNP2, Ppat, PPC Synthetase, PRIM1, PRPS2, PRPS3, PRPSAP2, Psf1, PU.1, R2, Rpp21, SAMHD1, UPRT, and XTP3TPA.Activator of:
ADE2, ADK, CNT3, GMPS, ITPase, NUDT15, PNP, and UCK1.Substrate of:
dCK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clofarabine, 10 mg | sc-278864 | 10 mg | $185.00 | |||
Clofarabine, 50 mg | sc-278864A | 50 mg | $781.00 |