Clarithromycin CAS: 81103-11-9
MF: C38H69NO13
MW: 747.95
A macrolide antibiotic and protein synthesis inhibitor.

Clarithromycin (CAS 81103-11-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Clarithromycin is rated 5.0 out of 5 by 1.
5
1
4
0
3
0
2
0
1
0
备用名: Biaxin; Cyllind; Klacid
应用; Clarithromycin is a macrolide antibiotic and protein synthesis inhibitor
CAS号码: 81103-11-9
纯度: ≥98%
分子量: 747.95
分子式: C38H69NO13
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Clarithromycin is a 14-member ring macrolide antibiotic and 6-O-methyl derivative of erythromycin. Clarithromycin has reported bacteriostatic action against gram-positive bacteria and some gram-negative bacteria including anaerobes. Similar to other macrolide antibiotics, this antibiotic is believed to function via binding of the ribosome within the microorganism. Studies have noted that Clarithromycin appears to bind specifically to the 50S ribosomal subunit, thus inhibiting DNA translation and inhibiting bacterial growth. This compound is both a substrate and inhibitor of CYP3A4.


参考文献

1. Goldman, R.C., et al. 1994. Antimicrob. Agents Chemother. 38: 1496-1500. PMID: 7979278
2. Champney, W.S. and Miller, M. 2002. Curr. Microbiol. 44: 418-424. PMID: 12000992
3. Mamelli, L., et al. 2005. J. Antimicrob. Chemother. 56: 491-497. PMID: 16055509
4. Sadeghi-Khomami, A., et al. 2008. Chem. Biol. 15: 739-749. PMID: 18635010

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in ethanol (<1 mg/ml), water (<1 mg/ml), acetone (50 mg/ml), DMSO (18 mg/ml), and methanol.
保存 :
Store at room temperature
熔点 :
222-231° C
沸点 :
805.48° C at 760 mmHg (Predicted)
密度 :
1.18 g/cm3 (Predicted)
折射率 :
n20D 1.53 (Predicted)
光学活性 :
α20/D -92°, c = 1 in chloroform
IC50 :
Streptococcus pneumoniae 5635: IC50 = 90 nM; Mdr-1: IC50 = 3.8 µM (human); Toxoplasma gondii 2F-1 expressing yellow fluorescent protein infected : IC50 = 31 µM; HERG: IC50 = 33.1 µM (human)
Ki 数据 :
CYP3A4: Ki= 5.49 µM (human)
pK值 :
pKa: 13.08 (Predicted), 8.16 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
KF4997000
PubChem CID :
默克索引 :
14: 2239
MDL 号码 :
MFCD00865140
Beilstein 注册 :
3581974
SMILES :

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

Clarithromycin (CAS 81103-11-9)  产品相关文献索引

看其他用户如何应用Clarithromycin (CAS 81103-11-9).点击进入浏览PubMed条目 .

引用1 - 11

PMID: # 33552084  Ngwa, DN.|Singh, SK.|Agrawal, A.| et al. 2020. Front Immunol. 11: 620784.

引用1 - 11
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 132ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话(021) 800-820-8626。 版权 ©, 2007-2021圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。