Ciglitazone CAS: 74772-77-3
MF: C18H23NO3S
MW: 333.44
An inhibitor of HUVEC differentiation and angiogenesis that stimulates adipogenesis.

Ciglitazone (CAS 74772-77-3)

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同义词: U-63287
应用; An inhibitor of HUVEC differentiation and angiogenesis that stimulates adipogenesis
CAS号码: 74772-77-3
纯度: ≥98%
分子量: 333.44
分子式: C18H23NO3S
* 参考分析证明 大量特定数据 (包括水 含量).
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Ciglitazone is an antihyperglycemic agent of the thiazolidinedione structural class. It displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice and is a selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits HUVEC differentiation and angiogenesis and also stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. This compound is at least 33-fold selective over PPARα and δ.


参考文献

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3. Cantello, B.C., et al. 1994. J. Med. Chem. 37: 3977-3985. PMID: 7966158
4. Willson, T.M., et al. 1996. J. Med. Chem. 39: 665-668. PMID: 8576907
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6. Xin, X., et al. 1999. J. Biol. Chem. 274: 9116-9121. PMID: 10085162
7. Benvenuti, S., et al. 2007. J. Endocrinol. Invest. 30: RC26-RC30. PMID: 17993761

用法 :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
物理状态 :
Solid
溶解度 :
Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml), 1eq. NaOH (100 mM), DMF (~16 mg/ml), 1:4 solution of DMSO:PBS (pH 7.2) (~400 µg/ml), and water (400 µg/ml) at 25° C.
保存 :
Store at 4° C
熔点 :
251.08° C (Predicted)
沸点 :
~504.5° C at 760 mmHg (Predicted)
密度 :
~1.2 g/cm3 (Predicted)
折射率 :
n20D 1.57 (Predicted)
IC50 :
PPARγ ligand-binding domain: EC5050 = 3.0 µM; Monoamine oxidase B: IC50 = 225 nM (human)
pK值 :
pKa: 6.36 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
XJ5813700
PubChem CID :
2750
MDL 号码 :
MFCD00865499
SMILES :
CC1(CCCCC1)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

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引用1 - 99

PMID: # 20093366  Wei, S. et al. 2010. J. Biol. Chem. 285: 9780-9791.

PMID: # 16711003  Zhang, W. et al. 2006. J. Huazhong Univ. Sci. Technol. Med. Sci. 26: 36-39.

PMID: # 15699354  Kolluri SK et al. 2005. Proc. Natl. Acad. Sci. USA. 102(7): 2525-2530.

PMID: # 12421816  Dang, ZC. et al. 2003. J. Biol. Chem. 278: 962-967.

PMID: # 11590167  Fu, M. et al. 2001. J. Biol. Chem. 276: 45888-45894.

PMID: # 10358062  Morrison, R.F. et al. 1999. J. Biol. Chem. 274: 17088-17097.

PMID: # 8505086  Pershadsingh, HA. et al. 1993. Hypertension. 21: 1020-1023.

PMID: # 3689881  Thurlby, PL. et al. 1987. Biosci. Rep. 7: 573-577.

Pan, H et al. The Chinese-German Journal of Clinical Oncology.

引用1 - 99
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