Chlorofluoroacetic acid (CAS 471-44-3)
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Chlorofluoroacetic acid (CFAA) is a halogenated carboxylic acid in many applications, including in the synthesis of polymers and other organic compounds. Chlorofluoroacetic acid is a highly reactive compound useful in a variety of chemical reactions, including oxidation, halogenation, and substitution reactions. It is a nucleophile that can form a covalent bond with several electron-deficient species, such as carbonyl compounds. Studies have strong inhibitory effects on aconitase, an enzyme that participates in the Krebs cycle. Chlorofluoroacetic acid exhibits inhibitory actions on various other enzymes, such as glycogen phosphorylase, phosphofructokinase, and pyruvate kinase. It hinders the activity of several enzymes involved in the metabolism of carbohydrates, lipids, and proteins.
Chlorofluoroacetic acid (CAS 471-44-3) References
- Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues. | Lantum, HB., et al. 2002. Drug Metab Dispos. 30: 616-25. PMID: 12019185
- Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1). | Lantum, HB., et al. 2002. Chem Res Toxicol. 15: 957-63. PMID: 12119007
- Nephrotoxicity of chlorofluoroacetic acid in rats. | Lantum, HB., et al. 2002. Toxicol Sci. 70: 261-8. PMID: 12441371
- Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. | Lim, CE., et al. 2004. Am J Pathol. 165: 679-93. PMID: 15277241
- Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene. | Hargus, SJ., et al. 1991. Biochemistry. 30: 717-21. PMID: 1988059
- Susceptibility to breast cancer and three polymorphisms of GSTZ1. | Saadat, I., et al. 2012. DNA Cell Biol. 31: 337-41. PMID: 21823988
- Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate. | Li, W., et al. 2012. Drug Metab Dispos. 40: 232-9. PMID: 22028318
- Characterization of catalytic activity and structure of selenocysteine-containing hGSTZ1c-1c based on site-directed mutagenesis and computational analysis. | Yu, Y., et al. 2013. IUBMB Life. 65: 163-70. PMID: 23299908
- Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration. | Jahn, SC., et al. 2018. Biochem Pharmacol. 152: 236-243. PMID: 29626439
- Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine. | Dekant, W., et al. 1987. Proc Natl Acad Sci U S A. 84: 7443-7. PMID: 3478703
- Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide. | Yamane, D., et al. 2022. Chem Sci. 13: 3027-3034. PMID: 35432850
- Metabolism of 1,2-dichloro-1-fluoroethane and 1-fluoro-1,2,2-trichloroethane: electronic factors govern the regioselectivity of cytochrome P450-dependent oxidation. | Yin, H., et al. 1996. Chem Res Toxicol. 9: 50-7. PMID: 8924616
- Reactivity of haloketenes and halothioketenes with nucleobases: reactions in vitro with DNA. | Müller, M., et al. 1998. Chem Res Toxicol. 11: 464-70. PMID: 9585477
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chlorofluoroacetic acid, 1 g | sc-300362 | 1 g | $208.00 | |||
Chlorofluoroacetic acid, 5 g | sc-300362A | 5 g | $624.00 |