Centrin-3 Antibody (SS12): sc-100933
- Centrin-3 Antibody (SS12) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against recombinant Centrin-3 of human origin
- recommended for detection of Centrin-3 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Centrin-3 Antibody (SS12). This work is in progress.
QUICK LINKS
Centrin-3 Antibody (SS12) is a mouse monoclonal IgG2b antibody that detects Centrin-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Centrin-3 is a crucial member of the EF-hand type calcium-binding protein family, which plays a significant role in the organization and function of centrosomes. Centrin-3 is primarily located in the centrosomes, where anti-Centrin-3 antibody (SS12) can detect essential functions in proper duplication and organization of centrioles, as well as maintenance of spindle pole morphology during cell division. Defects in centrosome function can lead to severe consequences, including genomic instability and cancer. Centrin-3′s interactions with other proteins involved in the cell cycle further underscore a critical role in cellular organization and division. With an ability to facilitate accurate segregation of chromosomes, Centrin-3 is vital for maintaining cellular integrity and function, making Centrin-3 (SS12) antibody an invaluable tool for researchers studying cell division and related processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Centrin-3 Antibody (SS12) References:
- A role for centrin 3 in centrosome reproduction. | Middendorp, S., et al. 2000. J Cell Biol. 148: 405-16. PMID: 10662768
- Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. | Laoukili, J., et al. 2000. J Cell Sci. 113 (Pt 8): 1355-64. PMID: 10725219
- The cloning and expression characterization of the centrosome protein genes family (centrin genes) in rat testis. | Sun, X., et al. 2002. Sci China C Life Sci. 45: 655-62. PMID: 18762898
- Differential expression of centrosomal proteins at different stages of human glioma. | Loh, JK., et al. 2010. BMC Cancer. 10: 268. PMID: 20529377
- Differential expression of centrosome-associated proteins in human brain tumors: a possible role of hNinein isoform 6 in cell differentiation. | Loh, JK., et al. 2012. Biofactors. 38: 470-7. PMID: 23047184
- The two human centrin homologues have similar but distinct functions at Tetrahymena basal bodies. | Vonderfecht, T., et al. 2012. Mol Biol Cell. 23: 4766-77. PMID: 23087207
- Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function. | Sawant, DB., et al. 2015. Mol Biol Cell. 26: 3741-53. PMID: 26354417
- FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration. | Fung, E., et al. 2018. EMBO Rep. 19: PMID: 29348145
- ACTG1 and TLR3 are biomarkers for alcohol-associated hepatocellular carcinoma. | Gao, B., et al. 2019. Oncol Lett. 17: 1714-1722. PMID: 30675230
- Interactome Analysis Reveals a Link of the Novel ALMS1-CEP70 Complex to Centrosomal Clusters. | Woerz, F., et al. 2024. Mol Cell Proteomics. 23: 100701. PMID: 38122899
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Centrin-3 Antibody (SS12) | sc-100933 | 50 µg/0.5 ml | $339.00 |