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possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Carcinoembryonic antigen (CEA) is one of the most commonly used tumor markers in serum immunoassay determinations of carcinoma. Members of the CEACAM (carcinoembryonic antigen-related cell adhesion molecule) family contain a single N domain, with structural homology to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), also known as BGP or BGP1, is a 526 amino acid protein that exists as seven alternatively spliced isoforms, some of which localize to the cell membranes, while others are secreted. One of several members of the CEACAM family, CEACAM1 contains one Ig-like V-type domain and three Ig-lik C2-type domains and is thought to play a role in a variety of cellular activities, including angiogenesis, apoptosis, arrangement of tissue three-dimensional structure and modulation of innate and adaptive immune responses. Additionally, CEACAM1 is underexpressed in colorectal cancers, suggesting a role in tumor suppression.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can CEACAM1：sc-59812 FITC（not the sc-59812） monoclonal antibody be used for detection of CEACAM1 of human origin by WB, IP, IF and ELISA？
Asked by: DiDi
Thank you for your question. This antibody is available directly conjugated to FITC (sc-59812 FITC) and recommended for use in the following applications: IF, IHC(P) and FCM. We do not recommend using the FITC conjugated primary antibody for Western blot (WB), immunoprecipitation (IP) or ELISA.
Answered by: Technical Support
Date published: 2017-06-01
Can CEACAM1 (GM8G5): sc-59812 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?
Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CEACAM1 (GM8G5): sc-59812 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
Did you test cross-reactivity of your GM-8G5 and the other mAb with other members of the human CEACAM protein family (3-21)? In fact except granulocyte none leukocyte subtype shows such an high CEACAM1 expression in FACScan as you show here...
Asked by: Anonymous
Concerning your mAb GM8G5 is it really binding to the A2 domain of human CEACAM1? Thus it would not recognize theCEACAM1-3 is-forms. You should mention this in your information about the mAbs.