Date published: 2025-9-9
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CEACAM1 Antibody (GM8G5) - Flow Cytometry - Image 14479
CEACAM1 抗体 (GM8G5): sc-59812. 用 CEACAM1 抗体 (GM8G5), 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738 染色的人类外周血白细胞的间接 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.
CEACAM1 Antibody (GM8G5) - Flow Cytometry - Image 14479
CEACAM1 抗体 (GM8G5): sc-59812. 用 CEACAM1 抗体 (GM8G5), 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738 染色的人类外周血白细胞的间接 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.
CEACAM1 抗体 (GM8G5): sc-59812. 用 CEACAM1 抗体 (GM8G5), 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738 染色的人类外周血白细胞的间接 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.

CEACAM1 抗体 (GM8G5): sc-59812

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说明书
  • CEACAM1抗体(GM8G5)是小鼠单克隆IgG1 κ, 在3篇文献中引用，规格为200 µg/ml
  • 免疫human物种的CEACAM1
  • 推荐用于 human 来源的CEACAM1 WB, IP, IF 和 ELISA检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是CEACAM1 Antibody (GM8G5) for WB applications. 的首选辅助检测试剂，这些试剂现与CEACAM1 Antibody (GM8G5) 打包提供（请参阅下面的订购信息）。

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関連項目

额外CEACAM抗体，包括CEACAM1, CEACAM16, CEACAM19, CEACAM2, CEACAM20, CEACAM3, CEACAM5, CEACAM6和CEACAM7

癌胚抗原（CEA）是血清免疫测定癌症中最常用的肿瘤标志物之一。CEACAM（癌胚抗原相关细胞粘附分子）家族的成员包含一个单一的N结构域，与免疫球蛋白可变区具有结构同源性，随后是数量可变的类似免疫球蛋白恒定区的A和/或B结构域。CEACAM1（癌胚抗原相关细胞粘附分子1），也称为BGP或BGP1，是一种由526个氨基酸组成的蛋白质，存在七种可选剪接的异构体，其中一些集中在细胞膜上，而另一些则被分泌出去。作为CEACAM家族的几个成员之一，CEACAM1包含一个类似Ig的V型结构域和三个类似Ig的C2型结构域，被认为在多种细胞活动中发挥作用，包括血管生成、细胞凋亡、组织三维结构的排列以及先天性和适应性免疫反应的调节。此外，CEACAM1在结直肠癌中低表达，提示其在肿瘤抑制中发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CEACAM1 抗体 (GM8G5) 参考文献:

  1. CEACAM1：免疫的接触依赖性控制。  |  Gray-Owen, SD. and Blumberg, RS. 2006. Nat Rev Immunol. 6: 433-46. PMID: 16724098
  2. 恶性黑色素瘤中的CEACAM1：诊断和治疗靶点。  |  Sapoznik, S., et al. 2012. Curr Top Med Chem. 12: 3-10. PMID: 22196267
  3. CEACAM1调节TIM-3介导的耐受性和衰竭。  |  Huang, YH., et al. 2015. Nature. 517: 386-90. PMID: 25363763
  4. CEACAM1：在黑素细胞转化中的表达和作用。  |  Turcu, G., et al. 2016. Dis Markers. 2016: 9406319. PMID: 27642217
  5. CEACAM1在免疫中的结构和功能及其治疗意义。  |  Kim, WM., et al. 2019. Semin Immunol. 42: 101296. PMID: 31604530
  6. EpCAM高表达肝癌干细胞通过上调CEACAM1抵抗自然杀伤细胞介导的细胞毒性。  |  Park, DJ., et al. 2020. J Immunother Cancer. 8: PMID: 32221015
  7. 表达CbpF的E. coli激活CEACAM1。  |  Shhadeh, A., et al. 2021. Front Cell Infect Microbiol. 11: 699015. PMID: 34395310
  8. 中性粒细胞CEACAM1通过调节肝移植中的S1PR2/S1PR3轴来决定对NETosis的敏感性。  |  Hirao, H., et al. 2023. J Clin Invest. 133: PMID: 36719377
  9. 低氧诱导因子-1&α对 CEACAM1 的替代剪接；增强小鼠和人类对肝缺血的耐受性。  |  Dery, KJ., et al. 2023. Sci Transl Med. 15: eadf2059. PMID: 37531413
  10. CEACAM1作为口腔癌的分子靶标。  |  Ma, S., et al. 2023. Aging (Albany NY). 15: 8137-8154. PMID: 37589542

订购信息

产品名称产品编号规格价格数量收藏夹

CEACAM1 抗体 (GM8G5)

sc-59812
200 µg/ml
$316.00

CEACAM1 (GM8G5): m-IgG Fc BP-HRP 套装

sc-539141
200 µg Ab; 10 µg BP
$354.00

CEACAM1 (GM8G5): m-IgG1 BP-HRP 套装

sc-541289
200 µg Ab; 20 µg BP
$354.00

CEACAM1 抗体 (GM8G5) FITC

sc-59812 FITC
200 µg/ml
$330.00

CEACAM1 抗体 (GM8G5) PE

sc-59812 PE
200 µg/ml
$343.00

Did you test cross-reactivity of your GM-8G5 and the other mAb with other members of the human CEACAM protein family (3-21)? In fact except granulocyte none leukocyte subtype shows such an high CEACAM1 expression in FACScan as you show here...

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Concerning your mAb GM8G5 is it really binding to the A2 domain of human CEACAM1? Thus it would not recognize theCEACAM1-3 is-forms. You should mention this in your information about the mAbs. 

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Can CEACAM1：sc-59812 FITC（not the sc-59812） monoclonal antibody be used for detection of CEACAM1 of human origin by WB, IP, IF and ELISA？

Asked by: DiDi
Thank you for your question. This antibody is available directly conjugated to FITC (sc-59812 FITC) and recommended for use in the following applications: IF, IHC(P) and FCM. We do not recommend using the FITC conjugated primary antibody for Western blot (WB), immunoprecipitation (IP) or ELISA.
Answered by: Technical Support
Date published: 2017-06-01

Can CEACAM1 (GM8G5): sc-59812 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CEACAM1 (GM8G5): sc-59812 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Great indirect FCM analysis of human peripheralGreat indirect FCM analysis of human peripheral blood leukocytes stained with CEACAM1 . -SCBT QC
Date published: 2014-02-03
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CEACAM1 抗体 (GM8G5) is rated 4.0 out of 5 by 1.
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