Date published: 2026-10-22
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Cdc6 Antibody (DCS-180) - Western Blotting - Image 15223
Cdc6 抗体 (DCS-180): sc-56273. 对 HeLa 全细胞裂解液中 Cdc6 的表达进行 Western 印迹分析.
Cdc6 抗体 (DCS-180): sc-56273. 对 HeLa 全细胞裂解液中 Cdc6 的表达进行 Western 印迹分析.

Cdc6 抗体 (DCS-180): sc-56273

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说明书
  • Cdc6抗体(DCS-180)是小鼠单克隆IgG1 κ, 在2篇文献中引用，规格为200 µg/ml
  • 针对全长Cdc6，human起源
  • 推荐用于 mouse, rat 和 human 来源的Cdc6 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Cdc6 (180.2): sc-9964，可查看有标记的 Cdc6 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是Cdc6 Antibody (DCS-180) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与Cdc6 Antibody (DCS-180) 搭配使用（请参阅下面的订购信息）。
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基因信息
说明书与实验方案
研究信息

関連項目

额外Cdc抗体，包括Cdc11, Cdc123, Cdc13, Cdc14 Phosphatase, Cdc16, Cdc2, Cdc20B, Cdc25, Cdc26, Cdc27, Cdc28, Cdc34, Cdc37, Cdc4, Cdc40和Cdc42

细胞周期事件受细胞周期蛋白依赖性激酶（Cdks）的顺序激活和失活以及细胞周期蛋白的水解调节。在细胞周期的不同阶段需要细胞分裂控制（Cdc）基因。Cdc25A、Cdc25B和Cdc25C蛋白酪氨酸磷酸酶通过使Cdc2 p34在调节性酪氨酸残基上脱磷酸化而发挥有丝分裂激活剂的作用。Cdc6是酿酒酵母Cdc6的人类同源物，参与DNA复制的启动。Cdc37似乎能促进Cdk4/细胞周期蛋白D1复合物的形成，并已显示能与HSP 90形成稳定的复合物。Cdc34、Cdc27和Cdc16起泛素结合酶的作用。Cdc34被认为是酿酒酵母Cdc34的结构和功能同源物，对G1到S期的转变至关重要。Cdc16和Cdc27是APC（x复合物）的组成部分，该复合物使细胞周期蛋白B泛素化，导致细胞周期蛋白B/Cdk复合物降解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdc6 抗体 (DCS-180) 参考文献:

  1. CDK 赋予 Cdc6 进入 S 期的许可。  |  Ayad, NG. 2005. Cell. 122: 825-7. PMID: 16179249
  2. Cdc6：一种三功能AAA+ ATP酶，在控制G（1）-S转换和细胞存活方面发挥核心作用。  |  Okayama, H. 2012. J Biochem. 152: 297-303. PMID: 22908236
  3. Cdc6 以依赖细胞周期的方式定位于 S 期和 G2 期中心体。  |  Kim, GS., et al. 2015. Biochem Biophys Res Commun. 456: 763-7. PMID: 25498505
  4. 依赖 SCF（细胞周期蛋白 F）的 CDC6 降解可抑制 DNA 的再复制。  |  Walter, D., et al. 2016. Nat Commun. 7: 10530. PMID: 26818844
  5. Cdc6和Cdt1在乳腺癌中的预后意义  |  Mahadevappa, R., et al. 2017. Sci Rep. 7: 985. PMID: 28428557
  6. Cdc6 中断会导致胰腺癌细胞中心体异常和染色体不稳定。  |  Youn, Y., et al. 2020. Sci Rep. 10: 16518. PMID: 33020506
  7. Cdc6表达增加与透明细胞肾细胞癌患者预后不良有关  |  Yicong, Y., et al. 2021. Front Oncol. 11: 666418. PMID: 34136398
  8. LINC01088/miR-22/CDC6轴通过激活PI3K/AKT通路调控前列腺癌进展  |  Li, J., et al. 2023. Mediators Inflamm. 2023: 9207148. PMID: 37501932
  9. Cdc6的N端区域可特异性识别人类DNA G-四联体。  |  Geng, Y., et al. 2024. Int J Biol Macromol. 260: 129487. PMID: 38237821
  10. Cdc6 与 DNA 复制：仅限于不起眼的起源。  |  Heichman, KA. 1996. Bioessays. 18: 859-62. PMID: 8939063

订购信息

产品名称产品编号规格价格数量收藏夹

Cdc6 抗体 (DCS-180)

sc-56273
200 µg/ml
$322.00

Cdc6 (DCS-180): m-IgG Fc BP-HRP 套装

sc-551935
200 µg Ab; 10 µg BP
$361.00

What is the recommended starting dilution for Western blot for Cdc6 (DCS-180): sc-56273 monoclonal antibody?

Asked by: Randy McDonald
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-56273.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Technical Support
Date published: 2017-03-01
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Rated 3 out of 5 by HC from Worked with transfected lysate by WB withWorked with transfected lysate by WB with some background -SCBT QC
Date published: 2015-02-15
Rated 4 out of 5 by QZ from Performs well in WesternPerforms well in Western, good signal strength in HeLa. -SCBT QC
Date published: 2014-12-13
Rated 5 out of 5 by T_ from The ORC3 (scThe ORC3 (sc-23888), Cdc6 (sc-56273) and secondary antibody (sc-2063) work great
Date published: 2012-05-07
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Cdc6 抗体 (DCS-180) is rated 4.0 out of 5 by 3.
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