Date published: 2025-9-6

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CCDC6 抗体 (Q-23): sc-100309

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说明书
  • CCDC6 抗体 Q-23 是小鼠单克隆 IgG1 κ,CCDC6抗体, 在1篇文献中引用,规格为100 µg/ml
  • 免疫human物种的重组CCDC6
  • 推荐用于 human 来源的CCDC6 WB, IP 和 ELISA检测
  • 关于如何获取CCDC6 (Q-23): sc-100309免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是CCDC6 Antibody (Q-23) for WB applications. 的首选辅助检测试剂,这些试剂现与CCDC6 Antibody (Q-23) 打包提供(请参阅下面的订购信息)。

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関連項目

CCDC6抗体(Q-23)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测人类来源的CCDC6蛋白。抗CCDC6抗体(Q-23)可作为非结合单克隆同种型抗体使用。CCDC6,也称为coiled-coil domain containing 6、H4、PTC、TPC或TST1,是一种585个氨基酸的细胞骨架蛋白,在细胞结构和功能中起着至关重要的作用。CCDC6主要表达于全身各种组织,其特点是α螺旋构象和亮氨酸拉链结构域,有助于与其他蛋白质相互作用。值得注意的是,CCDC6是RET受体酪氨酸激酶(一种参与胶质细胞系衍生神经营养因子信号转导的原癌基因)和血小板衍生生长因子受体β(PDGFR-β,一种间充质和胶质衍生细胞的促分裂素)的融合伴侣。CCDC6在染色体重组中起着重要作用,可导致致癌融合事件,特别是在各种癌症中,如人类乳头状甲状腺癌和慢性粒细胞白血病。这些融合产物在正常细胞中不存在,这强调了CCDC6在癌症生物学中的重要性,并突出了CCDC6(Q-23)抗体在研究中用于了解肿瘤发生分子机制的实用性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CCDC6 抗体 (Q-23) 参考文献:

  1. H4(D10S170)是甲状腺乳头状癌中经常发生重排的基因,在伴有t(5;10)(q33;q22)的非典型慢性髓性白血病中与血小板衍生生长因子受体β基因融合。  |  Schwaller, J., et al. 2001. Blood. 97: 3910-8. PMID: 11389034
  2. 人类甲状腺细胞系和甲状腺乳头状癌标本中 H4 和 PTEN 基因(H4/PTEN)之间的新型非克隆染色体内重排的特征。  |  Puxeddu, E., et al. 2005. Mutat Res. 570: 17-32. PMID: 15680400
  3. 一名慢性粒单核细胞白血病患者的 H4/D10S170 与 PDGFRbeta 融合以及对伊马替尼的长期反应。  |  Drechsler, M., et al. 2007. Ann Hematol. 86: 353-4. PMID: 17211520
  4. H4(D10S170) 蛋白参与了 ATM 依赖性 DNA 损伤反应。  |  Merolla, F., et al. 2007. Oncogene. 26: 6167-75. PMID: 17420723
  5. H4(D10S170)启动子区域和寡聚结构域的特征,H4是一种经常与ret原癌基因重排的基因。  |  Tong, Q., et al. 1995. Oncogene. 10: 1781-7. PMID: 7753554
  6. 参与体内 RET 重排的基因 H4 (D10S170) 的克隆和特征描述。  |  Grieco, M., et al. 1994. Oncogene. 9: 2531-5. PMID: 8058316
  7. 携带 RET/PTC1 癌基因的转基因小鼠出现乳腺和皮肤腺肿瘤。  |  Portella, G., et al. 1996. Oncogene. 13: 2021-6. PMID: 8934550
  8. 亮氨酸拉链介导的二聚化对 PTC1 的致癌活性至关重要。  |  Tong, Q., et al. 1997. J Biol Chem. 272: 9043-7. PMID: 9083029

订购信息

产品名称产品编号规格价格数量收藏夹

CCDC6 抗体 (Q-23)

sc-100309
100 µg/ml
$333.00

CCDC6 (Q-23): m-IgG Fc BP-HRP 套装

sc-539682
100 µg Ab; 10 µg BP
$354.00

CCDC6 (Q-23): m-IgG1 BP-HRP 套装

sc-541656
100 µg Ab; 20 µg BP
$354.00

Does it recognize CCDC6-RET fusion protein that includes the first 101 aa of CCDC6? Thank you!

Asked by: vjr97
thank you for your question. The antiobdy's epitope region is not within this amino acid range, so the antibody would not be able to detect that particular fragment.
Answered by: Tech Support Europe
Date published: 2025-02-04

For Western Blot, is it recommended to use denatured or non-denatured conditions with CCDC6 (Q-23): sc-100309 antibody?

Asked by: jenniferc
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
  • y_2025, m_8, d_29, h_8CST
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Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with FBW7 knockout HCT116 and DLD1, FBW7 mutant LS411N, SW1463, SW48, HCT8, and SW837, and Lim1215 cell lysates in published research -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from Strong positive band observed in WB in KStrong positive band observed in WB in K-562 whole cell lysate. -SCBT QC
Date published: 2015-06-25
Rated 4 out of 5 by from Robust band seen in WB in human CCDC6 transfectedRobust band seen in WB in human CCDC6 transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-01-09
Rated 4 out of 5 by from Large amount of signal observed in WB inLarge amount of signal observed in WB in human CCDC6 transfected 293T whole cell lysate. -SCBT QC
Date published: 2014-08-12
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CCDC6 抗体 (Q-23) is rated 4.3 out of 5 by 4.
  • y_2025, m_8, d_29, h_8
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