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CB2/Cannabinoid Receptor 2/CNR2 Antibody (3C7) - Western Blotting - Image 368036
CB2 抗体 (3C7): sc-293188. HL-60 (A), Jurkat (B), MOLT-4 (C) 和 IB4 (D) 全细胞裂解液中 CB2 表达的 Western 印迹分析.
CB2/Cannabinoid Receptor 2/CNR2 Antibody (3C7) - Western Blotting - Image 368036
CB2 抗体 (3C7): sc-293188. HL-60 (A), Jurkat (B), MOLT-4 (C) 和 IB4 (D) 全细胞裂解液中 CB2 表达的 Western 印迹分析.
CB2/Cannabinoid Receptor 2/CNR2 Antibody (3C7) - Western Blotting - Image 347542
CB2 抗体 (3C7): sc-293188. 未转染 (A) 和转染 CB2 (B) 的 293T 全细胞裂解液中 CB2 表达的 Western 印迹分析.
CB2/Cannabinoid Receptor 2/CNR2 Antibody (3C7) - Western Blotting - Image 348458
CB2 抗体 (3C7): sc-293188. 人重组 CB2 融合蛋白的 Western 印迹分析.
CB2 抗体 (3C7): sc-293188. HL-60 (A), Jurkat (B), MOLT-4 (C) 和 IB4 (D) 全细胞裂解液中 CB2 表达的 Western 印迹分析.

CB2/Cannabinoid Receptor 2/CNR2 抗体 (3C7): sc-293188

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说明书
  • CB2/Cannabinoid Receptor 2/CNR2 抗体 3C7 是小鼠单克隆 IgG1 κ，CB2/Cannabinoid Receptor 2/CNR2抗体, 在26篇文献中引用，规格为100 µg/ml
  • 针对human起源的部分重组CB2蛋白（氨基酸302-360）
  • 推荐用于 human 来源的CB2 WB, IP, IF 和 ELISA检测
  • 关于如何获取CB2/Cannabinoid Receptor 2/CNR2 (3C7): sc-293188的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成CB2/Cannabinoid Receptor 2/CNR2 抗体 (3C7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
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関連項目

CB2抗体（3C7）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附测定（ELISA）检测人类CB2。抗CB2抗体（3C7）可作为非结合型同种型抗体使用。CB2是大麻素受体家族的一员，主要在免疫细胞中表达，这与主要在脑中表达的CB1不同。这种独特的表达模式表明CB2在调节免疫反应和炎症方面发挥着重要作用，因此CB2成为治疗各种免疫相关疾病的潜在靶点。大麻素激活CB2可产生抗炎作用，这对关节炎和多发性硬化症等疾病的治疗非常重要。此外，CB2与特定蛋白（如β-arrestins）的相互作用会影响下游信号通路，从而影响细胞对大麻素的反应。了解这些相互作用以及CB2激活的功能意义对于开发靶向疗法至关重要，这些疗法可利用大麻素的治疗潜力，同时最大限度地减少精神活性作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CB2/Cannabinoid Receptor 2/CNR2 抗体 (3C7) 参考文献:

  1. 2-arachidonoylglycerol 而非 N-棕榈酰乙醇胺或 anandamide 是大麻素 CB2 受体生理配体的证据。比较各种大麻素受体配体在 HL-60 细胞中的激动活性。  |  Sugiura, T., et al. 2000. J Biol Chem. 275: 605-12. PMID: 10617657
  2. 内源性大麻素系统与大脑发育。  |  Fernández-Ruiz, J., et al. 2000. Trends Neurosci. 23: 14-20. PMID: 10631784
  3. 缺乏 CB1 受体的小鼠应激诱导的镇痛作用减弱，但外源性阿片类药物的作用并未减弱。  |  Valverde, O., et al. 2000. Eur J Neurosci. 12: 533-9. PMID: 10712632
  4. 分子克隆出一种也在睾丸中表达的人类大麻素受体。  |  Gérard, CM., et al. 1991. Biochem J. 279 (Pt 1): 129-34. PMID: 1718258
  5. 大麻素受体的结构和克隆 cDNA 的功能表达。  |  Matsuda, LA., et al. 1990. Nature. 346: 561-4. PMID: 2165569
  6. CB2的内源性大麻素参与调节RSV诱导的免疫。  |  Kaplan, BLF. 2018. Virulence. 9: 494-495. PMID: 29338583
  7. 针对大麻素cb1和cb2受体的变构调节剂：对药物发现的影响。  |  Gado, F., et al. 2019. Future Med Chem. 11: 2019-2037. PMID: 31517528
  8. 通过虚拟筛选和体外评估鉴定新型 CB2 配体。  |  Stasiulewicz, A., et al. 2023. J Chem Inf Model. 63: 1012-1027. PMID: 36693026
  9. 大麻素CB2受体可增强高脂饮食诱发的外周神经炎症。  |  Hosoki, H., et al. 2024. Life Sci. 355: 123002. PMID: 39173999
  10. 大麻素外周受体的分子特征。  |  Munro, S., et al. 1993. Nature. 365: 61-5. PMID: 7689702
  11. 小鼠 CB2 外周大麻素受体的分子克隆, 表达和功能。  |  Shire, D., et al. 1996. Biochim Biophys Acta. 1307: 132-6. PMID: 8679694
  12. CB1 受体基因敲除小鼠对大麻素反应迟钝，鸦片制剂的成瘾效应降低。  |  Ledent, C., et al. 1999. Science. 283: 401-4. PMID: 9888857

订购信息

产品名称产品编号规格价格数量收藏夹

CB2/Cannabinoid Receptor 2/CNR2 抗体 (3C7)

sc-293188
100 µg/ml
$316.00

Is there a blocking peptide for Anti-CB2/Cannabinoid Receptor 2/CNR2 Antibody (3C7): sc-293188 and for sc-518035?

Asked by: Metka Novak
Thank you for your question. No blocking peptide is available for either of these antibodies. If you are looking for a robust negative control for your experiments, please contact our technical service team for advice on solutions based on siRNA, shRNA, or CRISPR.
Answered by: Tech Support Europe
Date published: 2022-02-04

Will this antibody (sc-293188) work with IHC-P?

Asked by: juater05
Thank you for your question. Anti-CB2/Cannabinoid Receptor 2/CNR2 Antibody (3C7): sc-293188 is only recommended for detection of CB2 of human origin by WB, IP, IF and ELISA. Based on our tests we do not recommend it for IHC(P) applications.
Answered by: Tech Support Europe
Date published: 2021-04-28

will this antibody work with mouse CB2?

Asked by: Lawrence
Thank you for your question. Unfortunately we do not have any information on whether or not this antibody can pick up mouse samples. If you would like to try it, we would be happy to send you a sample size to try it out! Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you would like to try a sample.
Answered by: Tech Service
Date published: 2017-06-20

I am using CB2 (3C7): sc-293188 for immunofluorescence, what dilution of this antibody should I use?

Asked by: Dr Ninau Qelp
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Ottimo funzionamentoFunziona bene in WB con diluizione 1:500, banda chiara.
Date published: 2024-05-03
Rated 3 out of 5 by from Too many bandsI used the antibody for western blot on a mouse cell line, non happy with results. I tried several dilutions, but I always get many non specific bands
Date published: 2022-03-15
Rated 5 out of 5 by from SK030204V100CB2/Cannabinoid Receptor 2/CNR2 抗体 (3C7)抗体不错，实验很顺利，老师很满意。。下次还是买这个品牌的抗体。
Date published: 2022-02-07
Rated 1 out of 5 by from It doesn't work in miceWe have checked the antibody in spleen from wild type and CB2KO mice, by western blot. It did not show any signal which disappeared in the CB2KO samples. A non-specific signal appeared at 60KDa in both wild type and CB2KO samples.
Date published: 2018-04-19
Rated 5 out of 5 by from High specificity with dilutions around 1:200This antibody works well in Western blot (1:200) for mouse brain in alcoholism model
Date published: 2017-12-25
Rated 5 out of 5 by from Works well in monkey placentaThis antibody worked well for western blot of non-human primate placental tissue at dilution of 1:200. Strong bands at 60kDa and 45kDa with little to no background.
Date published: 2017-10-02
Rated 1 out of 5 by from Unable to rate this ab at this time.The CB2 receptor notoriously hard to pinpoint! Like all other commercial antibodies, this 3C7 antibody also shows a bright band at 60 kDa. But is it CB2? Is glycosylation really responsible for increase in the MW of the band? The predicted MW is only 40 kDa and the glycosylated form should be no more than 46 kDa. I did ICC with the same antibody. The staining mainly cytoplasmic not membrane. So, while the antibody obviously recognizes the fusion protein correctly as CB2 as shown by the data sheet, the 60 kDa I see in my cells and in the cells in the data sheet may or may not be CB2 receptor. I think SCBT should repeat the lysate blotting after peptide block to see if the 60 kDa band disappears.
Date published: 2017-07-19
Rated 5 out of 5 by from good band seenStrong band in WB in NIH/3T3 and HeLa whole cell lysates,recommend to other users.
Date published: 2017-06-03
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CB2/Cannabinoid Receptor 2/CNR2 抗体 (3C7) is rated 3.9 out of 5 by 10.
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