Date published: 2026-10-17
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cathepsin D Antibody (F-12) - Western Blotting - Image 150148
cathepsin D 抗体 (F-12): sc-374381. MCF7 (A) 和 ZR-75-1 (B) 全细胞裂解液中 cathepsin D 表达的 Western 印迹分析.
cathepsin D 抗体 (F-12): sc-374381. MCF7 (A) 和 ZR-75-1 (B) 全细胞裂解液中 cathepsin D 表达的 Western 印迹分析.

cathepsin D 抗体 (F-12): sc-374381

4.2(5)
寫評論提問
说明书
  • cathepsin D抗体(F-12)是小鼠单克隆IgG1 κ, 在3篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的cathepsin D的N-terminus的氨基酸69-97之间
  • 推荐用于 mouse, rat 和 human 来源的cathepsin D WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应，包括： porcine
  • 看 cathepsin D (D-7): sc-377299，可查看有标记的 cathepsin D 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是cathepsin D Antibody (F-12) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与cathepsin D Antibody (F-12) 打包提供（请参阅下面的订购信息）。
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関連項目

额外Cathepsin抗体，包括cathepsin 6, cathepsin A, cathepsin B, cathepsin C, cathepsin D, cathepsin E, cathepsin H, cathepsin K, cathepsin L, cathepsin O, cathepsin S, cathepsin V, cathepsin W, cathepsin Z和pan cathepsin

组织蛋白酶家族的蛋白水解酶包含几种不同类型的蛋白酶。半胱氨酸蛋白酶类包括组织蛋白酶B、L、H、K、S和O。天冬氨酸蛋白酶类由组织蛋白酶D和E组成。组织蛋白酶G属于丝氨酸蛋白酶类。大多数组织蛋白酶是溶酶体酶，每种酶都参与细胞代谢，参与肽合成和蛋白质降解等各种事件。组织蛋白酶还可以切割一些蛋白质前体，从而释放调节肽。组织蛋白酶D基因的启动子区包含五个Sp1结合位点和四个AP-2结合位点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

cathepsin D 抗体 (F-12) 参考文献:

  1. 氧化应激神经母细胞瘤细胞中的蛋白酶D-Bax死亡通路。  |  Castino, R., et al. 2007. Free Radic Biol Med. 42: 1305-16. PMID: 17395004
  2. 鞘脂对凝血酶 D 解肽活性的复杂调节。  |  Zebrakovská, I., et al. 2011. Biochim Biophys Acta. 1811: 1097-104. PMID: 21964280
  3. 在乳腺癌微环境中，组织蛋白酶D对胱抑素C的蛋白水解作用。  |  Laurent-Matha, V., et al. 2012. FASEB J. 26: 5172-81. PMID: 22898924
  4. 基于结构的非肽类组织蛋白酶D抑制剂的优化。  |  Grädler, U., et al. 2014. Bioorg Med Chem Lett. 24: 4141-50. PMID: 25086681
  5. VPS52通过胃癌中的组织蛋白酶D诱导细胞凋亡。  |  Zhang, J., et al. 2017. J Mol Med (Berl). 95: 1107-1116. PMID: 28791438
  6. 中华绒螯蟹（Eriocheir sinensis）中参与Spiroplasma eriocheiris感染的蛋白酶D的特征。  |  Ning, M., et al. 2018. Dev Comp Immunol. 86: 1-8. PMID: 29709775
  7. 作为组织蛋白酶D抑制剂的塔西酰胺B衍生物的设计、合成和生物活性。  |  Li, Z., et al. 2019. J Pept Sci. 25: e3154. PMID: 30734395
  8. 非酒精性脂肪肝患者的肌骨质疏松症与血浆中的钙蛋白D有关。  |  Ding, L., et al. 2021. Biomol Concepts. 12: 27-35. PMID: 33991468
  9. 结肠直肠癌中的组织蛋白酶D含量。与组织蛋白酶D活性和其他生物学参数的相关性：初步报告。  |  Tumminello, FM., et al. 1995. Oncology. 52: 237-42. PMID: 7715907
  10. Cathepsin D在体外具有类似β-分泌酶的特异性。  |  Chevallier, N., et al. 1997. Brain Res. 750: 11-9. PMID: 9098524

订购信息

产品名称产品编号规格价格数量收藏夹

cathepsin D 抗体 (F-12)

sc-374381
200 µg/ml
$322.00

cathepsin D (F-12): m-IgG Fc BP-HRP 套装

sc-540445
200 µg Ab; 10 µg BP
$361.00

cathepsin D (F-12): m-IgG1 BP-HRP 套装

sc-542128
200 µg Ab; 20 µg BP
$361.00

cathepsin D (F-12) 中和勝肽

sc-374381 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-374381 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by Magda888 from Low specificityAntibody detects pro-cathepsin D as well as light chain, at a concetration of 1:500. However specific band is surounded by much stronger unspecific bands. Because of that at short exposistion specific band is porly visible but at longer exposition it merges with neighbour unspecific bands.
Date published: 2020-01-21
Rated 5 out of 5 by Qifeng from dilution 1:1000Dilution 1:1000 works as well very low background, the best choice of antibody
Date published: 2017-05-14
Rated 5 out of 5 by liangq from successful experimentGreat result for WB in rat kidney tissue extract, dilution ratio 1:200.
Date published: 2017-04-25
Rated 5 out of 5 by MC from Produced great immunoperoxidase cytoplasmicProduced great immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human gall bladder tissue. -SCBT QC
Date published: 2015-01-29
Rated 5 out of 5 by JT from A good anitbody for use in WBA good anitbody for use in WB, sizable bands in both MCF7 and ZR-75-1 whole cell lysates. -SCBT QC
Date published: 2015-01-14
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cathepsin D 抗体 (F-12) is rated 4.2 out of 5 by 5.
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