Molecular structure of Caspase-3/7 Inhibitor I, CAS Number: 220509-74-0
Caspase-3/7 Inhibitor I (CAS 220509-74-0)
See product citations (4)
Alternate Names:
5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
Application:
Caspase-3/7 Inhibitor I is an inhibitor of caspase-3, caspase-7 and Caspase-9
CAS Number:
220509-74-0
Purity:
≥98%
Molecular Weight:
324.4
Molecular Formula:
C14H16N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Caspase-3/7 Inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app)= 60 nM) and caspase-7 (KI(app) = 170 nM). It is a weaker inhibitor of caspase-9 (KI(app) = 3.1 muM). Caspase-3/7 Inhibitor I has only a trivial effect (Ki(app) >25 muM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. It may act to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 muM). Caspase-3/7 Inhibitor I has also been reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 muM and 98% inhibition at 50 muM). Selectivity for caspases 3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.
Caspase-3/7 Inhibitor I (CAS 220509-74-0) References
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- Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. | Shimizu, K. and Sawasaki, T. 2013. FEBS Lett. 587: 2219-25. PMID: 23727203
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- Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes. | Han, A., et al. 2016. Anal Chem. 88: 3872-8. PMID: 26948051
- A FRET probe with AIEgen as the energy quencher: dual signal turn-on for self-validated caspase detection. | Yuan, Y., et al. 2016. Chem Sci. 7: 4245-4250. PMID: 30155071
- T-helper 1-type cytokines induce apoptosis and loss of HER-family oncodriver expression in murine and human breast cancer cells. | Namjoshi, P., et al. 2019. Oncotarget. 10: 6006-6020. PMID: 31666931
- Light-up bioprobe with aggregation-induced emission characteristics for real-time apoptosis imaging in target cancer cells. | Ding, D., et al. 2014. J Mater Chem B. 2: 231-238. PMID: 32261611
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Inhibitor of:
caspase-3, caspase-7, and Chemical and Peptide Caspase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Caspase-3/7 Inhibitor I, 1 mg | sc-293986 | 1 mg | $153.00 |