Caffeic acid phenethyl ester CAS: 104594-70-9
MF: C17H16O4
MW: 284.31
Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Caffeic acid phenethyl ester (CAS 104594-70-9)

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同义词: Phenethyl caffeate; CAPE
应用; Inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities
CAS号码: 104594-70-9
纯度: ≥98%
分子量: 284.31
分子式: C17H16O4
* 参考分析证明 大量特定数据 (包括水 含量).
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CAPE (Caffeic acid phenethyl ester) is a constituent of the propolis of honeybee hives and has been shown to contain inhibitory effects on induced papilloma promotion in mice. Studies have shown that CAPE acts as an anti-proliferative agent in over-productive cell growth. It is also shown that CAPE can cause DNA fragmentation and apoptosis which can have toxic results towards cloned rat embryo fibroblast (CREF) cells. In addition, CREF cells depleted of cellular glutathione (GSH) seemed to be more sensitive to CAPE-induced cell death.

CAPE has been reported to have anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. CAPE also inhibits HIV-1 integrase. The anti-inflammatory characteristics have been thought to be due to suppression of the lipoxygenase pathway of arachidonic acid metabolism by CAPE. Studies have also demonstrated CAPE to be a specific and potent inhibitor of activation of nuclear transcription factor NF kappa B, which is a protein complex that controls the transcription of DNA. CAPE (Caffeic Acid Phenethylester) is an inhibitor of ODC and Tyrosine Kinase.


参考文献

1. Sud'ina, G.F., et al. 1993. FEBS Lett. 329: 21-24. PMID: 7689063
2. Su, Z.Z., et al. 1995. Anticancer Res. 15: 1841-1848. PMID: 8572568
3. Chiao, C., et al. 1995. Cancer Res. 55: 3576-3583. PMID: 7543016
4. Huang, M.T., et al. 1996. Carcinogenesis. 17: 761-765. PMID: 8625488
5. Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93: 9090-9095. PMID: 8799159

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (10 mg/ml), ethanol (100 mM), ethyl acetate (50 mg/ml), methanol, acetone, and acetonitrile. Insoluble in water.
保存 :
Store at -20° C
熔点 :
173.38° C
沸点 :
~498.6° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.65
IC50 :
HIV-1 integrase: IC50 = 7 µM; MRP : IC50 = 15 µM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UD3334375
PubChem CID :
5281787
MDL 号码 :
MFCD00866470
SMILES :
C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O

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