Date published: 2025-9-7

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Brn-5/BRN5/POU6F1 抗体 (E-30): sc-81982

5.0(3)
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说明书
  • Brn-5/BRN5/POU6F1 抗体 E-30 是小鼠单克隆 IgG2a (kappa轻链),Brn-5/BRN5/POU6F1抗体,规格为100 µg/ml
  • 免疫human物种的重组Brn-5
  • 推荐用于 mouse, rat 和 human 来源的Brn-5 WB, IP 和 ELISA检测
  • 关于如何获取Brn-5/BRN5/POU6F1 (E-30): sc-81982免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Brn-5/BRN5/POU6F1 抗体 (E-30)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Brn-5抗体(E-30)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的Brn-5蛋白。抗Brn-5抗体(E-30)以非结合形式提供。Brn-5,也称为POU6F1、MPOU或TCFB1,在中枢神经系统发育中起着至关重要的作用,尤其是在胚胎发育过程中,Brn-5主要在发育中的大脑和脊髓中表达。作为转录因子Brn家族的一员,Brn-5有两个DNA结合结构域:POU特异性结构域和POU同源结构域,每个结构域都包含一个螺旋-转-螺旋结构,有利于DNA相互作用。这种结构特征对于功能至关重要,因为Brn-5与促皮质素释放激素元素结合具有高亲和力,从而增强催乳素基因的表达并激活Pit-1的表达,这是神经发育的重要过程。Brn-5调节基因表达的能力强调了其在神经元分化和中枢神经系统整体发育中的重要性,这使得抗Brn-5抗体(E-30)成为研究人员研究这些关键生物过程的有价值的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Brn-5/BRN5/POU6F1 抗体 (E-30) 参考文献:

  1. POU基因Brn-5由神经胶质蛋白诱导,仅限于髓鞘化的许旺细胞。  |  Wu, R., et al. 2001. Mol Cell Neurosci. 17: 683-95. PMID: 11312604
  2. 第六类 POU 蛋白 mPOU (Brn-5) 参与了 Pit-1 和 PRL 的基因表达。  |  Toda, K., et al. 2008. Mol Cell Endocrinol. 280: 20-9. PMID: 17933456
  3. 人类 Brn-5 转录因子与 DNA 复合物的结晶和初步 X 射线分析。  |  Pereira, JH., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 175-8. PMID: 18323601
  4. Brn-5是一种分歧的POU结构域因子,在新皮层第四层高度表达。  |  Andersen, B., et al. 1993. J Biol Chem. 268: 23390-8. PMID: 7901208
  5. Brn-3 类 POU 结构域因子可识别 DNA 功能元件,这些元件具有独特性, 均对称性,并且在进化过程中高度保守。  |  Gruber, CA., et al. 1997. Mol Cell Biol. 17: 2391-400. PMID: 9111308
  6. POU结构域基因在PNS衍生物干细胞系RT4-AC的系承后早期阶段有不同表达。  |  Donahue, LM. and Reinhart, AJ. 1998. Brain Res Dev Brain Res. 106: 1-12. PMID: 9554933
  7. 氯化钾抑制小脑颗粒神经元祖细胞的增殖  |  Cui, H. and Bulleit, RF. 1998. Brain Res Dev Brain Res. 106: 129-35. PMID: 9554981
  8. POU转录因子Brn-5的表达是中枢神经系统神经元末端分化的早期事件。  |  Cui, H. and Bulleit, RF. 1998. J Neurosci Res. 52: 625-32. PMID: 9669311
  9. 高度合作的同源二聚化是神经 POU 蛋白的一个保守特性。  |  Rhee, JM., et al. 1998. J Biol Chem. 273: 34196-205. PMID: 9852081

订购信息

产品名称产品编号规格价格数量收藏夹

Brn-5/BRN5/POU6F1 抗体 (E-30)

sc-81982
100 µg/ml
$316.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with Brn-5 (E-30): sc-81982 antibody?

Asked by: jerojero
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Great for Western BlotAntibody has been used for detection of POU6F1 in Schwann cells by Western Blot in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from the advantages of itBrn-5 contains two DNA-binding domains, namely the POU-specific domain and the POU homeodomain, which each contain an HTH (helix-turn-helix) motif. Brn-5 binds to CRH (corticotrophin-releasing hormone) elements with high affinity and is capable of both enhancing Prolactin gene expression and activating Pit-1 expression.
Date published: 2017-02-04
Rated 5 out of 5 by from Good signal acquired with Jurkat whole cellGood signal acquired with Jurkat whole cell lysate in Western. -SCBT QC
Date published: 2013-12-25
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Brn-5/BRN5/POU6F1 抗体 (E-30) is rated 5.0 out of 5 by 3.
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