Date published: 2025-9-6
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BMP-2/4 Antibody (H-1) - Western Blotting - Image 138291
BMP-2/4 抗体 (H-1): sc-137087. SHP-77 (A), A549 (B), SW480 (C) 和 COLO 320DM (D) 全细胞裂解液中 BMP-2/4 表达的 Western 印迹分析.
BMP-2/4 抗体 (H-1): sc-137087. SHP-77 (A), A549 (B), SW480 (C) 和 COLO 320DM (D) 全细胞裂解液中 BMP-2/4 表达的 Western 印迹分析.

BMP-2/4 抗体 (H-1): sc-137087

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说明书
  • BMP-2/4 抗体 H-1 是小鼠单克隆 IgG2a κ，BMP-2/4抗体, 在46篇文献中引用，规格为200 µg/ml
  • 免疫human物种的BMP-2/4的氨基酸300-350
  • BMP-2/4 抗体 (H-1) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 precursor and mature BMP-2 and BMP-4; 也和以下物种反应，包括： 和 canine, bovine and porcine
  • 抗BMP-2/4抗体（H-1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取BMP-2/4 (H-1): sc-137087的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是BMP-2/4 Antibody (H-1) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与BMP-2/4 Antibody (H-1) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

附加BMP抗体，包括BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8和BMP-9

BMP-2/4抗体（H-1）是一种IgG2aκ小鼠单克隆BMP-2/4抗体（也称为BMP2/4抗体或BMP2A/B抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的BMP-2/4蛋白。BMP-2/4抗体（H-1）既可作为非共轭抗BMP-2/4抗体形式，也可作为多种共轭形式的抗BMP-2/4抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®共轭物。肿瘤生长因子或TGFβ是调节细胞增殖和分化的分泌蛋白家族的原型成员。相关蛋白包括激活素和骨形态发生蛋白或BMP。与TGFβ一样，BMP通过由I型（TGFβ RI）和II型（TGFβ RII）受体组成的异聚体受体复合物（TGFβ R）发出信号。I型和II型受体都含有内在的丝氨酸/苏氨酸激酶活性。尽管对TGF β R下游的信号传导了解甚少，但已经有几种蛋白质被牵涉其中。六种TGFβ/BMP效应蛋白，即Smad1-6，可能起肿瘤抑制剂的作用。Smad蛋白被认为是转录因子，其作用类似于直接与活化受体结合的Stat家族，然后转位到细胞核。支持这一论断的证据来自观察到Smad3与TGFβ R复合物物理结合，并且在加入BMP-4后30-60分钟，Smad1被转位到细胞核中。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

BMP-2/4 抗体 (H-1) 参考文献:

  1. 骨生成蛋白-2。转化生长因子-β 超家族的一个新成员，在胚胎形成早期就已表达。  |  Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
  2. 转化生长因子-β 家族。  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
  3. 鉴定从牛骨中纯化的骨诱导蛋白中存在的转化生长因子 beta 家族成员。  |  Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
  4. BMP-2与致癌性之间的关联。  |  Skovrlj, B., et al. 2015. Spine (Phila Pa 1976). 40: 1862-71. PMID: 26274524
  5. BMP-2诱导的骨形成和神经炎症。  |  Nguyen, V., et al. 2017. J Orthop. 14: 252-256. PMID: 28367006
  6. 内源性BMP-4/ROS/COX-2介导的IPC和白藜芦醇减轻脑损伤。  |  Yan, Y., et al. 2019. Curr Pharm Des. 25: 1030-1039. PMID: 31113339
  7. 骨形成的新调节因子：分子克隆和活性。  |  Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
  8. GDF-9、BMP-15、BMP-4和EMMPRIN在卵泡发生和体外受精中的作用。  |  Fountas, S., et al. 2024. J Clin Med. 13: PMID: 38999341
  9. 表达重组 Vgr-1/BMP-6 的肿瘤可诱导体内纤维化和软骨内骨形成。  |  Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
  10. 一种作为 BMP 调节的转录激活因子的人类 Mad 蛋白。  |  Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
  11. 与受体相关的 Mad 同源物协同作用，成为 TGF-beta 反应的效应因子。  |  Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
  12. 一种新的 TGF-beta 超家族成员对小鼠骨骼肌质量的调节。  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

订购信息

产品名称产品编号规格价格数量收藏夹

BMP-2/4 抗体 (H-1)

sc-137087
200 µg/ml
$316.00

BMP-2/4 (H-1): m-IgG Fc BP-HRP 套装

sc-528858
200 µg Ab; 10 µg BP
$354.00

BMP-2/4 (H-1): m-IgGκ BP-HRP 套装

sc-521423
200 µg Ab, 40 µg BP
$354.00

BMP-2/4 (H-1): m-IgG2a BP-HRP 套装

sc-547193
200 µg Ab; 10 µg BP
$354.00

BMP-2/4 抗体 (H-1) AC

sc-137087 AC
500 µg/ml, 25% agarose
$416.00

BMP-2/4 抗体 (H-1) HRP

sc-137087 HRP
200 µg/ml
$316.00

BMP-2/4 抗体 (H-1) FITC

sc-137087 FITC
200 µg/ml
$330.00

BMP-2/4 抗体 (H-1) PE

sc-137087 PE
200 µg/ml
$343.00

BMP-2/4 抗体 (H-1) Alexa Fluor® 488

sc-137087 AF488
200 µg/ml
$357.00

BMP-2/4 抗体 (H-1) Alexa Fluor® 546

sc-137087 AF546
200 µg/ml
$357.00

BMP-2/4 抗体 (H-1) Alexa Fluor® 594

sc-137087 AF594
200 µg/ml
$357.00

BMP-2/4 抗体 (H-1) Alexa Fluor® 647

sc-137087 AF647
200 µg/ml
$357.00

BMP-2/4 抗体 (H-1) Alexa Fluor® 680

sc-137087 AF680
200 µg/ml
$357.00

BMP-2/4 抗体 (H-1) Alexa Fluor® 790

sc-137087 AF790
200 µg/ml
$357.00

I want to buy sc-137087 AF647. How much mL is it?

Asked by: Kwon YH
Thank you for your question. sc-137087 AF647 is 1 mL.
Answered by: Technical Service SH
Date published: 2025-08-08

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Tech Service 3
Date published: 2017-02-01

Do you have antibody specific for BMP2? I don't know if this antibody is for both BMP2/4, then should get two bands right?

Asked by: Shuaichen
Thank you for your question. sc-137087 will pick up both BMP-2 and BMP-4, so it is not specific for BMP-2. Whether you see one band or two depends on your samples. We do have an antibody specific for BMP-2, sc-6895. Here is the link: https://www.scbt.com/scbt/product/bmp-2-antibody-n-14
Answered by: Tech Service
Date published: 2016-09-27
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Rated 4 out of 5 by from Tested on oyster gonadWe tested this antibody on the gonad of the Pacific oyster, Crassostrea gigas, and we observed a good labeling on some cells of interest.
Date published: 2018-02-01
Rated 5 out of 5 by from 抗体很好用这个BMP2/4的抗体特异性很强，染出来的颜色很好看，背景很低，这次实验很成功，所以也推荐大家订购，
Date published: 2017-10-26
Rated 5 out of 5 by from 功能很出色，背景低，质量高我一个月前购买了此产品，效果很棒，功能很出色，背景低，质量高。推荐广大科研同志购买，是科研，发文必备。
Date published: 2017-10-26
Rated 4 out of 5 by from Good WBsc-137087 was used on mesenchymal stem cells at 1:1000 dilution; mature BMP-2 was detected at 54 kDa
Date published: 2017-09-28
Rated 5 out of 5 by from good quality for WBwe used this antibody to prove the component of the recombinant protein samples. It has been proved with two isoforms. We diluted this antibody by 1:1000 and incubate the strip at 4 ℃ overnight.
Date published: 2017-09-19
Rated 5 out of 5 by from Cell stainingMonoclonal antibody with excellent results in Western blot, analysis of BMP-2/4 expression in A549 whole cell lysates.
Date published: 2017-09-01
Rated 5 out of 5 by from Great antibodyI am happy I purchase this antibody. It was very stable and the result could be repeated.I will continue to use it.
Date published: 2017-02-13
Rated 5 out of 5 by from Helpful for those of usBMP-2/4 (H-1) antibody has worked very well in WB. It is predictable and reliable.Helpful for those of us.
Date published: 2017-02-05
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BMP-2/4 抗体 (H-1) is rated 4.7 out of 5 by 13.
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