Bimatoprost, free acid CAS: 38344-08-0
MF: C23H32O5
MW: 388.50
A metabolically stable analog of PGF.

Bimatoprost, free acid (CAS 38344-08-0)

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备用名: 17-Phenyl Trinor Prostaglandin F2-Alpha; 9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid; 17-phenyl trinor PGF2α
应用; Bimatoprost, free acid is a metabolically stable analog of PGF
CAS号码: 38344-08-0
纯度: >98%
分子量: 388.50
分子式: C23H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Bimatoprost, free acid is a metabolically stable analog of PGF and is a potent agonist for the PGF (FP receptor). It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF. Bimatoprost inhibits PGF binding with a Ki of 1.1 nM at the rat recombinant FP receptor expressed in CHO cells. The isopropyl ester of bimatoprost is slightly better than PGF isopropyl ester in reducing the intraocular pressure in the cat eye with no irritation.


参考文献

1. Balapure, A K., et al., 1989. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochemical pharmacology. 38(14): 2375-81. PMID: 2751699
2. Lake, S., et al., 1994. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS letters. 355(3): 317-25. PMID: 7988697

物理状态 :
Solid
溶解度 :
Soluble in PBS (pH 7.2) (~800 g/ml), ethanol (~100 mg/ml), DMF (~100 mg/ml), and DMSO (~100 mg/ml).
保存 :
Store at -20° C
熔点 :
244.30° C (Predicted)
沸点 :
597.38° C at 760 mmHg (Predicted)
密度 :
~1.2 g/cm3 (Predicted)
折射率 :
n20D 1.62 (Predicted)
Ki 数据 :
PGF2α: Ki= 1.1 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5283081
MDL 号码 :
MFCD00135254
SMILES :
C1[[email protected]@H]([[email protected]@H]([[email protected]]([[email protected]@H]1O)/C=C/[[email protected]](CCC2=CC=CC=C2)O)C/C=C\CCCC(=O)O)O

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