Date published: 2025-9-9
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Biglycan Antibody (3E2) - Western Blotting - Image 55188
Biglycan 抗体 (3E2): sc-100857. 未转染: sc-117752 (A) 和转染: sc-128099 (B) 293T 全细胞裂解液中 Biglycan 表达的 Western 印迹分析.
Biglycan Antibody (3E2) - Western Blotting - Image 55188
Biglycan 抗体 (3E2): sc-100857. 未转染: sc-117752 (A) 和转染: sc-128099 (B) 293T 全细胞裂解液中 Biglycan 表达的 Western 印迹分析.
Biglycan Antibody (3E2) - Western Blotting - Image 34229
Biglycan 抗体 (3E2): sc-100857. Hep G2 全细胞裂解液中 Biglycan 表达的 Western 印迹分析.
Biglycan 抗体 (3E2): sc-100857. 未转染: sc-117752 (A) 和转染: sc-128099 (B) 293T 全细胞裂解液中 Biglycan 表达的 Western 印迹分析.

Biglycan 抗体 (3E2): sc-100857

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说明书
  • Biglycan 抗体 3E2 是小鼠单克隆 IgG2a κ，Biglycan抗体, 在18篇文献中引用，规格为100 µg/ml
  • 针对全长重组蛋白human的Biglycan
  • 推荐用于 mouse, rat 和 human 来源的precursor and mature Biglycan WB, IP 和 ELISA检测
  • 关于如何获取Biglycan (3E2): sc-100857的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是Biglycan Antibody (3E2) 适用于 WB 应用。 的首选辅助检测试剂，这些试剂现与Biglycan Antibody (3E2) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

Biglycan抗体（3E2）是一种IgG2a κ小鼠单克隆Biglycan抗体（也称为BGN抗体或SLRR1A抗体），可通过WB、IP和ELISA检测小鼠、大鼠和人类来源的Biglycan蛋白。Biglycan抗体（3E2）可作为非偶联的抗Biglycan抗体使用。Biglycan是一种存在于细胞外基质中的I类富含亮氨酸的小蛋白聚糖（SLRP），影响骨细胞的分化和增殖。Biglycan在其氨基末端附近附着有两条硫酸软骨素葡糖胺聚糖（GAG）链，而与之密切相关的SLRP，即decorin，仅含有一条。Biglycan缺陷样本产生骨细胞前体的能力减弱，对TGFβ的反应减弱，胶原合成减少，凋亡增加。类风湿关节炎患者对Biglycan的免疫性增强，而骨关节炎患者则不然，这表明对SLRPs的较高免疫性可能在炎性风湿病的发病中起作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Biglycan 抗体 (3E2) 参考文献:

  1. 脂蛋白 E 与血管细胞外基质中 biglycan 蛋白核心结合的参与区：该脂蛋白的保留和抗动脉粥样硬化特性之间的潜在关系。  |  Klezovitch, O. and Scanu, AM. 2001. Trends Cardiovasc Med. 11: 263-8. PMID: 11709279
  2. Biglycan是amelogenin表达和釉质形成的抑制因子：一个新提出的假说。  |  Goldberg, M., et al. 2002. J Dent Res. 81: 520-4. PMID: 12147740
  3. 类风湿性关节炎或其他关节疾病患者滑液中与小蛋白多糖 biglycan 和 decorin 反应的抗体水平升高。  |  Polgár, A., et al. 2003. Rheumatology (Oxford). 42: 522-7. PMID: 12649398
  4. Biglycan 基因敲除小鼠：肌肉骨骼疾病的新模型。  |  Young, MF., et al. 2002. Glycoconj J. 19: 257-62. PMID: 12975603
  5. 富含亮氨酸的小蛋白聚糖在骨形成中的不同作用。  |  Waddington, RJ., et al. 2003. Eur Cell Mater. 6: 12-21; discussion 21. PMID: 14562268
  6. γ干扰素和肿瘤坏死因子α对培养人软骨细胞中编码 aggrecan, biglycan 和 decorin 核心蛋白的基因表达的影响。  |  Dodge, GR., et al. 1998. Arthritis Rheum. 41: 274-83. PMID: 9485085

订购信息

产品名称产品编号规格价格数量收藏夹

Biglycan 抗体 (3E2)

sc-100857
100 µg/ml
$333.00

Biglycan (3E2): m-IgG Fc BP-HRP 套装

sc-537291
100 µg Ab; 10 µg BP
$354.00

Biglycan (3E2): m-IgGκ BP-HRP 套装

sc-534523
100 µg Ab; 40 µg BP
$354.00

Which human tissue is it possible to use as positive control from paraffin embedded sections inorder to perform immunohistochemistry ?

Asked by: SVG92
Thank you for your question. Positive Controls for western blots are Biglycan (h2): 293T Lysate: sc-128099 or Hep G2 cell lysate: sc-2227. This particular protein has low tissue specificity, but can be found in connective tissues, especially in articular cartilages.
Answered by: Tech Support Europe
Date published: 2022-06-20

Can the Anti-Biglycan Antibody (3E2): sc-100857 be used for IHC? We have been using this antibody for WB of osteosarcoma cell extracts and IP (doi: 10.3390/cancers14051196.) and we want to try it for the histology of osteosarcoma biopsies. Thank you!

Asked by: Dranik
Thank you for your question. Anti-Biglycan Antibody (3E2): sc-100857 is only recommended for detection of precursor and mature Biglycan of mouse, rat and human origin by WB, IP and ELISA. Based on our tests with this product we do not recommend it for use in immunohistochemistry.
Answered by: Tech Support Europe
Date published: 2022-03-25

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Santa Cruz TS
Date published: 2017-01-27
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Rated 5 out of 5 by from 抗体很好用抗体很好用，下次还会订购，希望增加试用装， 抗体很好用，下次还会订购，希望增加试用装，多试用下，谢谢！！！
Date published: 2022-06-21
Rated 5 out of 5 by from Great antibody!This antibody works extremely well for WB on mouse cells.
Date published: 2019-08-19
Rated 5 out of 5 by from Strong Biglycan ab for WBsharp and clear banding in WB, highly recommeded. Several references in publications.
Date published: 2016-12-20
Rated 4 out of 5 by from Published data for IP and WB in mouse calvarialPublished data for IP and WB in mouse calvarial cells. -SCBT Publication Review
Date published: 2015-06-11
Rated 4 out of 5 by from Good specificity and signal strength in humanGood specificity and signal strength in human Biglycan transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-06-03
Rated 4 out of 5 by from Published ICC data for use in human mesenchymalPublished ICC data for use in human mesenchymal stem cells. -SCBT Publication Review
Date published: 2015-03-20
Rated 4 out of 5 by from Published data for WB in human fibrocytesPublished data for WB in human fibrocytes. -SCBT Publication Review
Date published: 2015-03-05
Rated 4 out of 5 by from Good antibody for WB in Hep G2 whole cell lysateGood antibody for WB in Hep G2 whole cell lysate. -SCBT QC
Date published: 2013-04-27
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Biglycan 抗体 (3E2) is rated 4.4 out of 5 by 8.
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