Benazeprilat (CAS 86541-78-8)

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备用名: USP Benazepril Related Compound C

应用； Benazeprilat is a potent ACE inhibitor

CAS号码: 86541-78-8

分子量: 396.44

分子式: C₂₂H₂₄N₂O₅

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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Benazeprilat is the active metabolite of benazepril (sc-337551), formed after cleavage of the ester group. Benazeprilat is a potent inhibitor of angiotensin-converting enzyme (ACE). This prevents the conversion of angiotensin I to the vasoconstrictor angiotensin II.

参考文献

1. Kitagawa, Hitoshi., et al., 2003. An angiotensin converting enzyme inhibitor, benazepril can be transformed to an active metabolite, benazeprilat, by the liver of dogs with ascitic pulmonary heartworm disease. The Journal of veterinary medical science / the Japanese Society of Veterinary Science. 65(6): 701-6. PMID: 12867730
2. Toutain, P L., et al., 2004. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors. Journal of veterinary pharmacology and therapeutics. 27(6): 515-25. PMID: 15601445
3. Wang, Xue-Ding., et al., 2007. Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection. Journal of pharmaceutical and biomedical analysis. 44(1): 224-30. PMID: 17289327

物理状态 :

Solid

溶解度 :

Soluble in DMSO.

保存 :

Store at -20° C

熔点 :

254-256° C

沸点 :

~711.3° C at 760 mmHg (Predicted)

密度 :

~1.3 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.64 (Predicted)

光学活性 :

α20/D -200.5°, c = 1 in 3% aqueous NH4OH

IC50 :

Angiotensin-converting enzyme: IC₅₀ = 1.7 nM (European rabbit)

pK值 :

pK_a: 2.17 (Predicted), pK_b: 8.35 (Predicted)

仅供科研使用。不可用于诊断或治疗。

PubChem CID :

5463984

MDL 号码 :

MFCD08060091

SMILES :

C1CC2=CC=CC=C2N(C(=O)[[email protected]]1N[[email protected]@H](CCC3=CC=CC=C3)C(=O)O)CC(=O)O

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