Date published: 2025-9-7
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BCoR Antibody (C-10) - Western Blotting - Image 323824
BCoR 抗体 (C-10): sc-514576. HeLa (A) 和 Y79 (B) 全细胞裂解液中 BCoR 表达的 Western 印迹分析.
BCoR Antibody (C-10) - Western Blotting - Image 323824
BCoR 抗体 (C-10): sc-514576. HeLa (A) 和 Y79 (B) 全细胞裂解液中 BCoR 表达的 Western 印迹分析.
BCoR Antibody (C-10) - Western Blotting - Image 378200
BCoR 抗体 (C-10): sc-514576. Western 印迹分析 Y79 全细胞裂解液中 BCoR 的表达. 所用检测试剂: m-IgGκ BP-HRP: sc-516102.
BCoR Antibody (C-10) - Western Blotting - Image 378205
BCoR 抗体 (C-10): sc-514576. Western 印迹分析 HeLa 全细胞裂解液中 BCoR 的表达. 所用检测试剂: m-IgGκ BP-HRP: sc-516102.
BCoR 抗体 (C-10): sc-514576. HeLa (A) 和 Y79 (B) 全细胞裂解液中 BCoR 表达的 Western 印迹分析.

BCoR 抗体 (C-10): sc-514576

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寫評論提問

说明书
  • BCoR 抗体 C-10 是小鼠单克隆 IgG1 κ，BCoR抗体, 在35篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列1-300位于human物种的BCoR的N-terminus
  • BCoR 抗体 (C-10) 推荐用于WB, IP, IF 和 ELISA，检测human 来源的 BCoR
  • 抗BCoR抗体（C-10）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取BCoR (C-10): sc-514576的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是BCoR Antibody (C-10) 适用于 WB 应用。 的首选辅助检测试剂，这些试剂现与BCoR Antibody (C-10) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 BCoR 抗体包括 BCORL2

BCoR抗体（C-10）是一种IgG1 κ小鼠单克隆BCoR抗体（也称为BCoR抗体），可通过WB、IP、IF和ELISA检测人源的BCoR蛋白。BCoR抗体（C-10）既可以是非偶联的抗BCoR抗体形式，也可以是多种偶联形式的抗BCoR抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Bcl-6是一种转录抑制因子，根据细胞类型可以促进或抑制细胞凋亡，并在正常免疫反应中发挥重要作用。Bcl-6负调控NFκB表达，从而抑制NFκB介导的细胞功能，在非霍奇金淋巴瘤中经常发现其表达失调。BCoR（BCL-6辅抑制因子）是一种由1755个氨基酸组成的蛋白质，与组蛋白去乙酰化酶（HDACs）结合，在转录水平上抑制Bcl-6。BCoR表达广泛，定位于细胞核，通过其3个ANK重复结构域与其他蛋白质相互作用。编码BCoR的基因发生突变会导致小眼畸形伴相关异常2，也称为无眼症，其特征为各种表现，如肾发育不全、智力迟钝、尿道下裂、小脑畸形和隐睾症。BCoR有四种异构体，这是由选择性剪接事件产生的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

BCoR 抗体 (C-10) 参考文献:

  1. 参与 BCL-6 抑制的新型核心抑制因子 BCoR。  |  Huynh, KD., et al. 2000. Genes Dev. 14: 1810-23. PMID: 10898795
  2. BCOR中不同类型的突变导致了眼球心室综合征和伦茨小眼症综合征。  |  Ng, D., et al. 2004. Nat Genet. 36: 411-6. PMID: 15004558
  3. 多聚酶群和 SCF 泛素连接酶存在于一个新型 BCOR 复合物中，该复合物被招募到 BCL6 靶标上。  |  Gearhart, MD., et al. 2006. Mol Cell Biol. 26: 6880-9. PMID: 16943429
  4. PQBP1 基因中两个碱基对的缺失与小眼症, 小头畸形和智力迟钝有缔合作用。  |  Martínez-Garay, I., et al. 2007. Eur J Hum Genet. 15: 29-34. PMID: 17033686
  5. 对Ring1B/Rnf2相互作用者的蛋白质组学分析发现了一种与Fbxl10/Jhdm1B组蛋白去甲基化酶和Bcl6相互作用核心抑制因子的新型复合物。  |  Sánchez, C., et al. 2007. Mol Cell Proteomics. 6: 820-34. PMID: 17296600
  6. BCOR 核心抑制肽与 BCL6 BTB 结构域二聚体复合物的结构。  |  Ghetu, AF., et al. 2008. Mol Cell. 29: 384-91. PMID: 18280243
  7. 转录核心抑制因子 Bcor 在胚胎干细胞分化和早期胚胎发育中的作用  |  Wamstad, JA., et al. 2008. PLoS One. 3: e2814. PMID: 18795143

订购信息

产品名称产品编号规格价格数量收藏夹

BCoR 抗体 (C-10)

sc-514576
200 µg/ml
$316.00

BCoR (C-10): m-IgG Fc BP-HRP 套装

sc-531167
200 µg Ab; 10 µg BP
$354.00

BCoR (C-10): m-IgGκ BP-HRP 套装

sc-524777
200 µg Ab, 40 µg BP
$354.00

BCoR 抗体 (C-10) AC

sc-514576 AC
500 µg/ml, 25% agarose
$416.00

BCoR 抗体 (C-10) HRP

sc-514576 HRP
200 µg/ml
$316.00

BCoR 抗体 (C-10) FITC

sc-514576 FITC
200 µg/ml
$330.00

BCoR 抗体 (C-10) PE

sc-514576 PE
200 µg/ml
$343.00

BCoR 抗体 (C-10) Alexa Fluor® 488

sc-514576 AF488
200 µg/ml
$357.00

BCoR 抗体 (C-10) Alexa Fluor® 546

sc-514576 AF546
200 µg/ml
$357.00

BCoR 抗体 (C-10) Alexa Fluor® 594

sc-514576 AF594
200 µg/ml
$357.00

BCoR 抗体 (C-10) Alexa Fluor® 647

sc-514576 AF647
200 µg/ml
$357.00

BCoR 抗体 (C-10) Alexa Fluor® 680

sc-514576 AF680
200 µg/ml
$357.00

BCoR 抗体 (C-10) Alexa Fluor® 790

sc-514576 AF790
200 µg/ml
$357.00

Hi, We are having an issue validating the lot of BCOR SC-514576 E1623 for immunohistochemistry on formalin fixed paraffin embeded tissue. We have used the previous lot E2616 with no issues. Has there been any issues reported with this lot. Thanks

Asked by: Louise
Thank you for your question. Please contact us directly so our technical service team can offer troubleshooting advice.
Answered by: Tech Support Europe
Date published: 2024-04-10

Does BCoR Antibody (C-10) been tested for detecting mouse BCOR protein ? It is unclear from the description on website as references (not citations!) stated on the santacruz website indicate ref 1,7 are mouse bcor protein and not human origin

Asked by: Zuzer
Thank you for your question. BCoR Antibody (C-10) is a mouse monoclonal antibody recommended for human samples .
Answered by: BlakeJ
Date published: 2023-12-18

i have order BCOR C-10 HRP FOR USE IN PARAFFINE EMBEDDED BLOCK ...USED TESTIS SECTIONS AS CONTROL BUT IS NOT GIVING RESULT....TRIED AT DILUTION 1.50,1:100,1:150 AT PH 6 ... KINDLY HELP ME OUT WHAT TO DO??????? I AM A P.G STUDENT

Asked by: AKANKSHA
Please reach out to our Technical Service team with the order#, Lot#, and Protocol used.
Answered by: Tech Sales
Date published: 2021-07-09

Kindly let us know the BCOR Aantibody (C-10) clone for use by IMMUNOHISTOCHEMISTRY NOT western blotting asap. Thanks.

Asked by: BharatRekhi
Thank you for your question. Our mouse monoclonal sc-514576, BCoR (C-10), is recommended for Western blot, IP and Immunofluorescence on fresh frozen tissues and cells. It has not been tested for IHC on paraffin sections and can not be warrantied for that use.
Answered by: Tech Service
Date published: 2020-02-10

Can BCoR Antibody (C-10): sc-514576 be used for detection of DOCK 8 in samples other than human?

Asked by: jenni
Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.
Answered by: Technical Support 6
Date published: 2018-07-11
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Rated 2 out of 5 by from Strong in WB, but fail to IF in mouse testis IFI tried from 1:100 to 1:20, and the citrate or EDTA or citrate-EDTA for heat antigenretriev, but all fail to stain in the mouse testis for IF-P and IF-Fr.
Date published: 2024-12-06
Rated 4 out of 5 by from はっきりとしたバンドが見えますサンプルを頂いて使用してみたのですが、バンドがとてもクリアで良かったので、新たに購入して使用しています。
Date published: 2023-03-24
Rated 5 out of 5 by from 功能很不错，值得购买。我一个月前购买了此产品，效果不错,而且文献上都推荐这个抗体。大家可以买来试一试。很不错很不错很不错。。。。。。。。。。
Date published: 2020-06-08
Rated 5 out of 5 by from Bonne fonctionnalitéNous avons l'anticorps depuis 1 an maintenant, et sommes très satisfaits.
Date published: 2020-04-14
Rated 2 out of 5 by from Buen resultado pero señal muy débilEl anticuerpo es bueno, pero tengo que utilizar una dilución muy pequeña (1/70) para poder ver la señal.
Date published: 2017-05-23
Rated 5 out of 5 by from Strong WBVery strong clear wester blot data, low background; much superior to polyclonal alternative
Date published: 2017-01-11
Rated 5 out of 5 by from Very Strong Signal in WBVery strong signal with no background, great for WB. Reliable antibody.
Date published: 2016-12-30
Rated 4 out of 5 by from We tried this antibody in human cell linesWe tried this antibody in human cell lines and got correct band at 1:500 dilution in WB.
Date published: 2015-09-15
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BCoR 抗体 (C-10) is rated 4.0 out of 5 by 8.
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