armadillo Antibody (F-6): sc-365793
- armadillo Antibody (F-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 39-67 near the N-terminus of armadillo of Dm origin
- recommended for detection of armadillo of d origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for armadillo Antibody (F-6) for WB applications. These reagents are now offered in bundles with armadillo Antibody (F-6) (see ordering information below).
QUICK LINKS
SEE ALSO...
Armadillo Antibody (F-6) is a mouse monoclonal IgG1 antibody that detects Armadillo in Drosophila species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Armadillo, the Drosophila homolog of β-catenin, plays a crucial role in cellular signaling and is integral to the Wnt signaling pathway, which is vital for regulating cell proliferation, differentiation, and fate determination during development. Anti-Armadillo antibody (F-6) recognizes a protein primarily located at adherens junctions, where Armadillo interacts with the tumor suppressor APC (Adenomatous polyposis coli) to influence cellular adhesion and communication. This localization helps maintain tissue integrity and regulates processes such as retinal fecundity and programmed cell death, which are essential for proper development and homeostasis. Anti-Armadillo antibody (F-6) serves as an invaluable tool for researchers studying these critical biological processes in Drosophila and can provide insights into the mechanisms underlying similar pathways in higher eukaryotes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
armadillo Antibody (F-6) References:
- Armadillo repeat proteins: beyond the animal kingdom. | Coates, JC. 2003. Trends Cell Biol. 13: 463-71. PMID: 12946625
- The armadillo protein p0071 regulates Rho signalling during cytokinesis. | Wolf, A., et al. 2006. Nat Cell Biol. 8: 1432-40. PMID: 17115030
- The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10. | Mou, Z., et al. 2009. J Biol Chem. 284: 13629-13640. PMID: 19304657
- Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure. | Watson, RP., et al. 2014. Structure. 22: 985-95. PMID: 24931467
- Metazoan evolution of the armadillo repeat superfamily. | Gul, IS., et al. 2017. Cell Mol Life Sci. 74: 525-541. PMID: 27497926
- Peptide-Guided Assembly of Repeat Protein Fragments. | Michel, E., et al. 2018. Angew Chem Int Ed Engl. 57: 4576-4579. PMID: 29480529
- Modular peptide binders - development of a predictive technology as alternative for reagent antibodies. | Gisdon, FJ., et al. 2022. Biol Chem. 403: 535-543. PMID: 35089661
- The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex resembling the vertebrate adherens junction. | Peifer, M. 1993. J Cell Sci. 105 (Pt 4): 993-1000. PMID: 8227220
- An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling. | Orsulic, S. and Peifer, M. 1996. J Cell Biol. 134: 1283-300. PMID: 8794868
- Armadillo and dTCF: a marriage made in the nucleus. | Cavallo, R., et al. 1997. Curr Opin Genet Dev. 7: 459-66. PMID: 9309175
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
armadillo Antibody (F-6) | sc-365793 | 200 µg/ml | $322.00 | |||
armadillo Antibody (F-6): m-IgG Fc BP-HRP Bundle | sc-540368 | 200 µg Ab; 10 µg BP | $361.00 | |||
armadillo Antibody (F-6): m-IgG1 BP-HRP Bundle | sc-542075 | 200 µg Ab; 20 µg BP | $361.00 | |||
armadillo (F-6) Neutralizing Peptide | sc-365793 P | 100 µg/0.5 ml | $69.00 |