ARL6IP4 Antibody (ZZ-8): sc-81894

ARL6IP4 Antibody (ZZ-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects ARL6IP4 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ARL6IP4 (ZZ-8) antibody is available as a non-conjugated anti-ARL6IP4 antibody. ARL6IP4, also known as ADP-ribosylation-like factor 6 interacting protein 4, SR-25, or SRp25, is a hydrophilic nuclear protein consisting of 360 amino acids, predominantly expressed in the testis and thymus. ARL6IP4 plays a crucial role in RNA splicing, as indicated by its serine-arginine repeat (SR) domain, which is characteristic of many pre-mRNA splicing factors. ARL6IP4 contains at least fifteen putative phosphorylation sites, highlighting its potential for post-translational modifications that can regulate activity and interactions. ARL6IP4 functionally interacts with Rac 1, a GTP-binding protein of the Ras superfamily, suggesting involvement in the regulation of Rac 1-dependent signaling pathways, which are essential for various cellular processes, including cell migration and proliferation. At the amino acid level, human and mouse ARL6IP4 proteins exhibit 77.7% identity, underscoring the conservation of this protein′s function across species.

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ARL6IP4 Antibody (ZZ-8) References:

1. Molecular cloning and expression analysis of a putative nuclear protein, SR-25.  |  Sasahara, K., et al. 2000. Biochem Biophys Res Commun. 269: 444-50. PMID: 10708573
2. Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region.  |  Shink, E., et al. 2005. Am J Med Genet B Neuropsychiatr Genet. 135B: 50-8. PMID: 15768393
3. Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants.  |  Ben-Ari, S., et al. 2006. J Neurochem. 97 Suppl 1: 24-34. PMID: 16635247
4. Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse.  |  Lehrmann, E., et al. 2006. PLoS One. 1: e114. PMID: 17205118
5. Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis.  |  Lee, SC., et al. 2007. Proteomics. 7: 4112-22. PMID: 17952876

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARL6IP4 Antibody (ZZ-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ARL6IP4 Antibody (ZZ-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARL6IP4 Antibody (ZZ-8) Specifications

Alternate Product Name: ARL6IP4

Product Clone Name: ZZ-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 261-361

Epitope Target: ARL6IP4

Epitope Species: human

Product Reactivity/Detection: ARL6IP4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ARL6IP4 Antibody (ZZ-8): N/A