Amphotericin B CAS: 1397-89-3
Amphotericin B is an antifungal and useful cell culture antibiotic.

Amphotericin B (CAS 1397-89-3)

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备用名: Fungizone
应用; Amphotericin B is an antifungal and useful cell culture antibiotic
CAS号码: 1397-89-3
分子量: 924.09
分子式: C47H73NO17
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Amphotericin B, Streptomyces sp. is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. The compounds mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B′s antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B, Streptomyces sp. was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D (sc-200906) sensitivity in drug resistant HELA cells in vitro.


参考文献

1. Medoff, J., et al. 1975. Cancer Res. 35: 2548-2552. PMID: 1149049
2. Presant, C.A., et al. 1984. Cancer Treat Rep. 68: 651-654. PMID: 6201270
3. Barth, C., et al. 1993. Biophys. J. 64: 92-97. PMID: 7679300
4. Charak, B.S., et al. 1994. Br. J. Haematol. 88: 693-698. PMID: 7529537
5. Sundar, S., et al. 2010. N. Engl. J. Med. 362: 504-512. PMID: 20147716

用法 :
Store at 4°C for up to 2 weeks.
For long term storage, store at -20°C.
物理状态 :
Solid
来源于 :
Streptomyces sp.
溶解度 :
Soluble in DMSO (30-40 mg/ml), acidic water (pH 2) or basic water (pH 11) (~0.1 mg/ml), DMF (2-4 mg/ml), DMF + 1 M HCl (3:1) (60-80 mg/ml), and methanol (slightly). Insoluble in ether.
保存 :
Desiccate at -20° C
沸点 :
~1140.4° C at 760 mmHg (Predicted)
密度 :
~1.3 g/cm3 (Predicted)
折射率 :
n20D 1.61 (Predicted)
IC50 :
Trichophyton mentagrophytes: IC50 = 0.02 µg/ml (Trichophyton mentagrophytes); Leishmania donovani: IC50 = 0.06 µg/ml (Leishmania donovani); Candida albicans: EC5050 = 0.25 µg/ml (Candida albicans)
pK值 :
pKa: 5.5, 10.0, pKb: 8.12
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
BU2625000
PubChem CID :
5280965
默克索引 :
14: 585
MDL 号码 :
MFCD00877763
EC号码 :
215-742-2
Beilstein 注册 :
78342

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PMID: # 30157175  Najafov, A. et al. 2018. PLoS Biol. 16: e2005756.

PMID: # 31907385  J. Hum. Genet.

PMID: # 32723117  J Drug Target. 1-34.

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