Molecular structure of Amphotericin B, CAS Number: 1397-89-3
Amphotericin B (CAS 1397-89-3)
See product citations (10)
Alternate Names:
Fungizone
Application:
Amphotericin B is an antifungal and useful cell culture antibiotic
CAS Number:
1397-89-3
Molecular Weight:
924.09
Molecular Formula:
C47H73NO17
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Amphotericin B is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. The compounds mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B′s antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D (sc-200906) sensitivity in drug resistant HeLa cells in vitro.
Amphotericin B (CAS 1397-89-3) References
- Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. | Noel, GJ. 1999. J Pediatr. 135: 399. PMID: 10523149
- Mortality and costs of acute renal failure associated with amphotericin B therapy. | Bates, DW., et al. 2001. Clin Infect Dis. 32: 686-93. PMID: 11229835
- Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells. | Medoff, J., et al. 1975. Cancer Res. 35: 2548-52. PMID: 1149049
- Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS. | Johnson, PC., et al. 2002. Ann Intern Med. 137: 105-9. PMID: 12118965
- Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion. | Vogelsinger, H., et al. 2006. J Antimicrob Chemother. 57: 1153-60. PMID: 16627591
- Optimizing efficacy of amphotericin B through nanomodification. | Vyas, SP. and Gupta, S. 2006. Int J Nanomedicine. 1: 417-32. PMID: 17722276
- Single-dose liposomal amphotericin B for visceral leishmaniasis in India. | Sundar, S., et al. 2010. N Engl J Med. 362: 504-12. PMID: 20147716
- Amphotericin B formulations: a comparative review of efficacy and toxicity. | Hamill, RJ. 2013. Drugs. 73: 919-34. PMID: 23729001
- Encochleated Amphotericin B: Is the Oral Availability of Amphotericin B Finally Reached? | Aigner, M. and Lass-Flörl, C. 2020. J Fungi (Basel). 6: PMID: 32443486
- A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptoccal meningitis. | Bennett, JE., et al. 1979. N Engl J Med. 301: 126-31. PMID: 449951
- Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung. | Presant, CA., et al. 1984. Cancer Treat Rep. 68: 651-4. PMID: 6201270
- Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro. | Charak, BS., et al. 1994. Br J Haematol. 88: 693-8. PMID: 7529537
- Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior. | Barth, C., et al. 1993. Biophys J. 64: 92-7. PMID: 7679300
- Lipid formulations of amphotericin B: recent progress and future directions. | Hiemenz, JW. and Walsh, TJ. 1996. Clin Infect Dis. 22 Suppl 2: S133-44. PMID: 8722841
- Lipid formulations of amphotericin B: clinical efficacy and toxicities. | Wong-Beringer, A., et al. 1998. Clin Infect Dis. 27: 603-18. PMID: 9770163
Inhibitor of:
2810008M24Rik, Aspergillus, C8orf40, Candida albicans, CCDC132, CRS1C-3, GRAMD1B, LIMP III, LOC643008, MANSC4, MENTHO, Na+/K+-ATPase β1, Pma1, Pneumocystis carinii, PRR24, Raftlin-2, Ssn6, and XKR4.Activator of:
AE2, ATP10C, C9orf91, CLPTM1, CRB3, Dengue Virus 2, Dpl, granzyme D, HL60 Antigen, Imp4, LOC284274, LOC339674, MANSC4, Mx2, Myeloid Marker, Na+/K+-ATPase α3, PrP, Sho1, and Tra-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amphotericin B, 100 mg | sc-202462 | 100 mg | $70.00 | |||
Amphotericin B, 500 mg | sc-202462A | 500 mg | $142.00 | |||
Amphotericin B, 1 g | sc-202462B | 1 g | $223.00 |