Date published: 2025-9-10

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Amphiphysin II 抗体 (D-3): sc-74486

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说明书
  • Amphiphysin II抗体(D-3)是小鼠单克隆IgG2a (kappa轻链),规格为200 µg/ml
  • 针对氨基酸421-520的图谱,在Amphiphysin II的内部区域,human起源
  • 推荐用于 mouse, rat 和 human 来源的all Amphiphysin II isoforms WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Amphiphysin II (2F11): sc-23918,可查看有标记的 Amphiphysin II 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRPm-IgG2a BP-HRP 是 Amphiphysin II 抗体 (D-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Amphiphysin II 抗体 (D-3) 组合成套装提供。 (请参阅下面的订购信息)。

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    関連項目

    双亲蛋白是一种富含脑的蛋白质,具有N端脂质相互作用,并作为二聚体发挥作用。双亲蛋白包含膜弯曲BAR结构域、中间网格蛋白和接头结合结构域以及C端SH3结构域。在脑中,双亲蛋白I和II形成异二聚体,通过其SH3结构域与网格蛋白相关GTP酶Dynamin结合。这种结合对于神经元中的突触小泡再循环至关重要,因为它发生在Dynamin与网格蛋白包被的凹坑结合以及随后的囊泡出芽之前。在其他组织中,双亲蛋白可能在其他膜弯曲和曲率稳定事件中发挥关键作用。哺乳动物双亲蛋白、双亲蛋白I和双亲蛋白II具有相似的整体结构。双亲蛋白II的一种普遍存在的剪接形式不含网格蛋白或接头相互作用,在肌肉组织中高度表达,并参与T管网络的形成和稳定。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Amphiphysin II 抗体 (D-3) 参考文献:

    1. 桥接整合素1(BIN1)在肝癌中作为潜在肿瘤抑制剂和预后标志物的特征。  |  Pan, K., et al. 2012. Mol Med. 18: 507-18. PMID: 22281836
    2. 阿尔茨海默氏症患者大脑中桥接整合蛋白1(BIN1)的表达增加,并与神经纤维缠结病理相关。  |  Holler, CJ., et al. 2014. J Alzheimers Dis. 42: 1221-7. PMID: 25024306
    3. 异丙肾上腺素促进快速肌动蛋白受体移动到桥联整合蛋白1(BIN1)组织的二聚体。  |  Fu, Y., et al. 2016. Circulation. 133: 388-97. PMID: 26733606
    4. 桥接整合蛋白1(BIN1)基因型通过改变神经元退化来调节阿尔茨海默病的风险。  |  Wang, HF., et al. 2016. J Alzheimers Dis. 52: 179-90. PMID: 27003210
    5. 双亲蛋白(BIN1)通过负调控动力蛋白2来促进肌肉的正常成熟。  |  Cowling, BS., et al. 2017. J Clin Invest. 127: 4477-4487. PMID: 29130937
    6. 心肌细胞的二元可塑性。  |  Jones, PP., et al. 2018. Front Physiol. 9: 1773. PMID: 30618792
    7. 缺氧诱导的外泌体circPDK1通过调节miR-628-3p/BPTF轴激活c-myc并降解BIN1,从而促进胰腺癌的糖酵解。  |  Lin, J., et al. 2022. J Hematol Oncol. 15: 128. PMID: 36068586
    8. 在IRSp53依赖性纤突形成过程中,BIN1调节肌动蛋白与膜的相互作用。  |  Picas, L., et al. 2024. Commun Biol. 7: 549. PMID: 38724689
    9. 揭示支持中心核肌病的BIN1-SH3相互作用组。  |  Zambo, B., et al. 2024. Elife. 13: PMID: 38995680
    10. BIN1缺乏可增强ULK3依赖性自噬通量,并减少小鼠海马神经元的树突大小。  |  Jin, Y., et al. 2025. Autophagy. 21: 223-242. PMID: 39171951

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Amphiphysin II 抗体 (D-3)

    sc-74486
    200 µg/ml
    $316.00

    Amphiphysin II (D-3): m-IgG Fc BP-HRP 套装

    sc-539527
    200 µg Ab; 10 µg BP
    $354.00

    Amphiphysin II (D-3): m-IgG2a BP-HRP 套装

    sc-546722
    200 µg Ab; 10 µg BP
    $354.00

    I am using Amphiphysin II (D-3): sc-74486 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

    Asked by: Cweed
    We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-02-24
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    Rated 5 out of 5 by from Superb immunoperoxidase cytoplasmic stainingSuperb immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human spleen tissue. -SCBT QC
    Date published: 2015-04-17
    Rated 5 out of 5 by from Positive results in western blot analysisPositive results in western blot analysis of Amphiphysin II expression in HeLa nuclear extract, Jurkat and SJRH30 whole cell lysates and rat skeletal muscle tissue extract. -SCBT QC
    Date published: 2015-04-06
    Rated 5 out of 5 by from Clean bands in western blot using truncatedClean bands in western blot using truncated human Amphiphysin II transfected 293T and HeLa whole cell lysates. -SCBT QC
    Date published: 2015-03-27
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    Amphiphysin II抗体 (D-3) is rated 5.0 out of 5 by 3.
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