Amentoflavone CAS: 1617-53-4
MF: C30H18O10
MW: 538.46
An anti-viral and anti-inflammatory agent that up-regulates PPAR-γ.

Amentoflavone (CAS 1617-53-4)

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应用; An anti-viral and anti-inflammatory agent that up-regulates PPAR-γ
CAS号码: 1617-53-4
分子量: 538.46
分子式: C30H18O10
* 参考分析证明 大量特定数据 (包括水 含量).
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Amentoflavone is a bioflavonoid that has anti-viral and anti-inflammatory properties. The compound has been observed to inhibit the expression of INOS, LPS-induced activation of NFκB p50 (NF-κ B), translocation of p65 by LPS and block IKKα(I-κ B α) degradation in macrophages. Amentoflavone has been shown to up-regulate PPAR-γ and block the induction of COX-2. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site. The compound has demonstrated anti-viral activity against respiratory syncytial virus (RSV), with an IC50 of 5.5 μg/ml. Amentoflavone has also pronounced inhibition at an IC50 = 14.9 +/- 1.9 nM of benzodiazepine binding in vitro.


参考文献

1. Baureithel, K.H., et al. 1997. Pharm Acta Helv. 72: 153-157. PMID: 9204773
2. Kim, H.K., et al. 1998. Arch. Pharm. Res. 21: 406-410. PMID: 9875467
3. Ma, S.C., et al. 2001. Biol. Pharm. Bull. 24: 311-312. PMID: 11256492
4. Banerjee, T., et al. 2002. Mol. Cell. Biochem. 238: 105-110. PMID: 12349896
5. Woo, E.R., et al. 2005. Pharmacol. Res. 51: 539-546. PMID: 15829434

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (partly).
保存 :
Store at 4° C
沸点 :
~910.5° C at 760 mmHg (Predicted)
密度 :
~1.7 g/cm3 (Predicted)
折射率 :
n20D 1.79 (Predicted)
IC50 :
BACE: IC50 = 1.54 µM (human); Mcl-1: IC50 = 1.63 µM (human); VCP: IC50 = 8.98 µM (human); NIH3T3: IC50 = 9.2 µM (mouse); group II sPLA2: IC50 = 23.8 µM (human)
Ki 数据 :
GABA-A receptor; anion channel: Ki= 6 nM (human); DOR-1: Ki= 36 nM (human); δ opioid receptor: Ki= 36.5 nM (pig); D3DR: Ki= 1.24 µM (human); SR-2C: Ki= 2.56 µM (human)
pK值 :
pKa: 6.01 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
5281600
MDL 号码 :
MFCD00017470
Beilstein 注册 :
380244
SMILES :
C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O

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