Ambroxol hydrochloride CAS: 23828-92-4
MF: C13H18Br2N2O•HCl
MW: 414.6
An expectorant antioxidant and antiinflammatory agent.

Ambroxol hydrochloride (CAS 23828-92-4)

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应用; An expectorant antioxidant and antiinflammatory agent
CAS号码: 23828-92-4
纯度: 98%
分子量: 414.6
分子式: C13H18Br2N2O•HCl
* 参考分析证明 大量特定数据 (包括水 含量).
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Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.


参考文献

1. Disse, B.G. 1987. Eur J Respir Dis Suppl. 153: 255-262. PMID: 3322865
2. Wilke, A., et al. 1987. Respiration. 52: 129-136. PMID: 3671891
3. Nowak, D., et al. 1995. Free Radic. Biol. Med. 19: 659-663. PMID: 8529925
4. Gibbs, B.F., et al. 1999. Inflamm. Res. 48: 86-93. PMID: 10202994
5. Stetinová, V., et al. 2004. Clin. Exp. Med. 4: 152-158. PMID: 15599665
6. Laurent, A., et al. 2004. Hepatology. 39: 1277-1285. PMID: 15122756
7. Su, X., et al. 2004. Intensive Care Med. 30: 133-140. PMID: 14504727
8. Beeh, K.M., et al. 2008. Eur. J. Med. Res. 13: 557-562. PMID: 19073395
9. Malerba, M., 2008. Expert Opin Drug Metab Toxicol. 4: 1119-1129. PMID: 18680446

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.
保存 :
Store at 4° C
熔点 :
>235° C (dec.)
IC50 :
tetrodotoxin (TTX)-resistant channels: IC50 = 35.2 µM; TTX-sensitive subtypes: IC50 = 111.5 µM
pK值 :
pKb: 8.69
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GV8423000
PubChem CID :
108013
默克索引 :
14: 386
MDL 号码 :
MFCD00078932
EC号码 :
242-500-3
SMILES :
C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl

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