Date published: 2025-9-6

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α-dystroglycan 抗体 (VIA41): sc-53986

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说明书
  • α-dystroglycan抗体(VIA41)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 针对纯化的rabbit来源的肌营养不良蛋白-糖蛋白复合物
  • 推荐用于 mouse, rat, human, bovine, rabbit 和 canine 来源的α-dystroglycan WB 和 IP检测
  • 看 α-dystroglycan (IIH6): sc-53987,可查看有标记的 α-dystroglycan 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是α-dystroglycan Antibody (VIA41) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与α-dystroglycan Antibody (VIA41) 搭配使用(请参阅下面的订购信息)。

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関連項目

α-dystroglycan Antibody (VIA41) 是一种小鼠单克隆 IgG1 抗体,可通过免疫印迹 (WB) 和免疫沉淀 (IP) 等应用检测小鼠、大鼠、人、牛、兔和犬样本中的α-dystroglycan。α-dystroglycan (VIA41) 抗体可识别一种主要位于细胞表面的蛋白质,α-dystroglycan 与各种细胞外基质成分(包括层粘连蛋白、Agrin 和 Perlecan)相互作用,促进这些分子组织成功能性结构。α-dystroglycan 的正确定位对神经肌肉接头处烟碱乙酰胆碱受体的聚集至关重要,而烟碱乙酰胆碱受体的聚集对有效的突触传递和肌肉收缩至关重要。α-dystroglycan (VIA41)单克隆抗体是研究人员在各种生物过程和疾病状态下研究这种蛋白质的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

α-dystroglycan 抗体 (VIA41) 参考文献:

  1. α-dystroglycan 的多重亲和力。  |  Sciandra, F., et al. 2013. Curr Protein Pept Sci. 14: 626-34. PMID: 24206164
  2. α-dystroglycan 和肌肉萎缩症的糖生物学。  |  Endo, T. 2015. J Biochem. 157: 1-12. PMID: 25381372
  3. 人类 α-肌收缩蛋白的结构灵活性。  |  Covaceuszach, S., et al. 2017. FEBS Open Bio. 7: 1064-1077. PMID: 28781947
  4. α-Dystroglycan/LG 结构域结合模式分析:研究调节分离 LG 结构域亲和力的蛋白质基团  |  Dempsey, CE., et al. 2019. Front Mol Biosci. 6: 18. PMID: 30984766
  5. 拉沙热病毒与 Matriglycan--α-Dystroglycan 上木糖和葡萄糖醛酸交替的聚合物--结合。  |  Joseph, S. and Campbell, KP. 2021. Viruses. 13: PMID: 34578260
  6. Sarcospan 可提高 α-肌张力障碍蛋白与层粘连蛋白的结合能力,从而改善 DMD,而与 Galgt2 无关。  |  Mamsa, H., et al. 2022. Hum Mol Genet. 31: 718-732. PMID: 34581784
  7. 海马腹侧糖基化α-Dystroglycan的缺乏为γ-氨基丁酸A型受体的不稳定性与雄性小鼠的抑郁样行为搭建了桥梁  |  Xie, WL., et al. 2022. Biol Psychiatry. 91: 593-603. PMID: 35063187
  8. 肌肉收缩蛋白上的 N 终止子结构域能使 LARGE1 延伸α-肌肉收缩蛋白上的 matriglycan,从而预防肌肉萎缩症。  |  Okuma, H., et al. 2023. Elife. 12: PMID: 36723429
  9. 在一家三级儿科神经肌肉中心就诊的韩国α-肌营养不良症相关肌肉营养不良症患者的表型和基因型差异很大。  |  Ko, YJ., et al. 2023. Neuromuscul Disord. 33: 425-431. PMID: 37087885
  10. α-dystroglycan N末端对 SARS-CoV-2 和包膜病毒具有广谱抗病毒作用。  |  Bigotti, MG., et al. 2024. Antiviral Res. 224: 105837. PMID: 38387750

订购信息

产品名称产品编号规格价格数量收藏夹

α-dystroglycan 抗体 (VIA41)

sc-53986
200 µg/ml
$316.00

α-dystroglycan (VIA41): m-IgG Fc BP-HRP 套装

sc-539019
200 µg Ab; 10 µg BP
$354.00

Are there any issues with using sc-53986: α-dystroglycan (VIA41) mouse monoclonal primary antibody on mouse samples?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-53986 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Good antibodyThe alpha-dystroglycan Antibody (VIA41): sc-53986 works well for Western blot applications, showing strong banding.
Date published: 2017-02-02
Rated 5 out of 5 by from Worked great in WB in mouse cell linesWorked great in WB in mouse cell lines- strong band of interest seen.
Date published: 2015-11-04
Rated 5 out of 5 by from Strong band of interest observed in WB inStrong band of interest observed in WB in bovine brain tissue extract. -SCBT QC
Date published: 2014-09-21
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α-dystroglycan 抗体 (VIA41) is rated 5.0 out of 5 by 3.
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