Date published: 2025-9-8
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Aldehyde dehydrogenase 1-L1/ALDH1L1 Antibody (YY8) - Western Blotting - Image 30634
ALDH1L1 抗体 (YY8): sc-100497. 对 NIH/3T3 全细胞裂解液中 ALDH1L1 的表达进行 Western 印迹分析.
ALDH1L1 抗体 (YY8): sc-100497. 对 NIH/3T3 全细胞裂解液中 ALDH1L1 的表达进行 Western 印迹分析.

Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 (YY8): sc-100497

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说明书
  • Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 YY8 是小鼠单克隆 IgG3 κ，Aldehyde dehydrogenase 1-L1/ALDH1L1抗体, 在9篇文献中引用，规格为50 µg/0.5 ml
  • 免疫human物种的重组ALDH1L1
  • 推荐用于 mouse, rat 和 human 来源的ALDH1L1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取Aldehyde dehydrogenase 1-L1/ALDH1L1 (YY8): sc-100497的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP 是Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 (YY8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 (YY8) 组合成套装提供。 (请参阅下面的订购信息)。

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研究信息

関連項目

此外 ALDH 抗体 包括 ALDH1, ALDH16A1, ALDH18A1, ALDH1A1, ALDH1A2, ALDH1B1, ALDH1L1, ALDH2, ALDH3A1和ALDH3A2

ALDH1L1抗体（YY8）是一种IgG3κ小鼠单克隆ALDH1L1抗体（也称为FDH抗体或FTHFD抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的ALDH1L1蛋白。ALDH1L1抗体（YY8）为非偶联型抗ALDH1L1抗体。醛脱氢酶（ALDHs）在酒精衍生的乙醛解毒、脂质过氧化以及皮质类固醇、生物源性胺和神经递质的代谢过程中，介导NADP+依赖的醛类氧化成酸。ALDH1L1（醛脱氢酶1家族成员L1），也称为FTHFD或10-FTHFD（10-甲酰基四氢叶酸脱氢酶），是一种在小脑发育过程中受调控的胞质蛋白。ALDH1L1与叶酸结合，催化10-甲酰基四氢叶酸（10-FTHF）转化为四氢叶酸（THF）。这表明ALDH1L1可能在调节细胞THF水平以及抑制细胞增殖（因为10-FTHF对嘌呤的合成至关重要）方面发挥作用。此外，ALDH1L1的过度表达可以在体外限制细胞增殖。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 (YY8) 参考文献:

  1. 醛脱氢酶在内源性和异生物代谢中的作用。  |  Vasiliou, V., et al. 2000. Chem Biol Interact. 129: 1-19. PMID: 11154732
  2. 人类醛脱氢酶：潜在的病理, 药理和毒理影响。  |  Sládek, NE. 2003. J Biochem Mol Toxicol. 17: 7-23. PMID: 12616643
  3. 叶酸代谢酶 ALDH1L1 被限制在早期中枢神经系统的中线，这表明它在人类神经管缺陷中发挥作用。  |  Anthony, TE. and Heintz, N. 2007. J Comp Neurol. 500: 368-83. PMID: 17111379
  4. CYPs 以外的酶参与了异种生物的氧化代谢。  |  Strolin Benedetti, M., et al. 2006. Expert Opin Drug Metab Toxicol. 2: 895-921. PMID: 17125408
  5. 一碳代谢基因的多态性与绝经后乳腺癌发病率的缔合作用。  |  Stevens, VL., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 1140-7. PMID: 17548676
  6. 单碳代谢基因多态性与澳大利亚人罹患非霍奇金淋巴瘤的风险。  |  Lee, KM., et al. 2007. Hum Genet. 122: 525-33. PMID: 17891500
  7. 星形胶质细胞, 神经元和少突胶质细胞转录组数据库：了解大脑发育和功能的新资源。  |  Cahoy, JD., et al. 2008. J Neurosci. 28: 264-78. PMID: 18171944
  8. 癌症中的ALDH1L1和ALDH1L2叶酸调节酶。  |  Krupenko, SA. and Krupenko, NI. 2018. Adv Exp Med Biol. 1032: 127-143. PMID: 30362096
  9. ALDH1L1叶酸酶的缺失为肿瘤进展提供了选择性代谢优势。  |  Krupenko, SA. and Krupenko, NI. 2019. Chem Biol Interact. 302: 149-155. PMID: 30794800
  10. 假定的肿瘤抑制剂ALDH1L1的结构。  |  Tsybovsky, Y., et al. 2022. Commun Biol. 5: 3. PMID: 35013550
  11. Aldh1l1-Cre/ER T2在唾液腺、胰腺和脾脏的非预期细胞类型中表达。  |  Nemeth, D., et al. 2023. MicroPubl Biol. 2023: PMID: 37273576
  12. 鉴定小鼠体内叶酸依赖性酶 10-甲酰四氢叶酸脱氢酶的遗传性缺乏。  |  Champion, KM., et al. 1994. Proc Natl Acad Sci U S A. 91: 11338-42. PMID: 7972060

订购信息

产品名称产品编号规格价格数量收藏夹

Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 (YY8)

sc-100497
50 µg/0.5 ml
$333.00

Aldehyde dehydrogenase 1-L1/ALDH1L1 (YY8): m-IgG3 BP-HRP 套装

sc-550383
50 µg Ab; 40 µg BP
$354.00

I need to use an antibody to detect the protein in samples of canine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Tech Service 3
Date published: 2017-02-02
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Rated 4 out of 5 by from Prodotto funzionanateHo provato questo anticorpo in immunofluorescenza, su fettine di midollo spinale di topo criostatate. Diluizione 1:100, funziona bene, il segnale è pulito e specifico. Non ho dato il massimo perchè facendo una co-immuno insieme ad un altro anticorpo, il segnale di ALDH1L1 diminuisce di intensità, ma nel complesso è un ottimo prodotto.
Date published: 2019-09-18
Rated 5 out of 5 by from clear western blot bandWe use this antibody for western blot and we got a clear band around the correct molecular weight
Date published: 2017-01-11
Rated 4 out of 5 by from Good specificity in WB in mouse transfectedGood specificity in WB in mouse transfected 293 and NIH/3T3 whole cell lysates. -SCBT QC
Date published: 2015-05-16
Rated 4 out of 5 by from Good IHC published data in human solid HNSCCGood IHC published data in human solid HNSCC tumors. -SCBT Publication Review
Date published: 2015-05-11
Rated 4 out of 5 by from Strong band in WB in human transfected 293TStrong band in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-06
Rated 4 out of 5 by from Robust signal in WB in NIH/3T3 whole cell lysateRobust signal in WB in NIH/3T3 whole cell lysate. -SCBT QC
Date published: 2015-03-13
Rated 4 out of 5 by from Great immunoperoxidase cytoplasmic stainingGreat immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded human kidney tissue. -SCBT QC
Date published: 2015-03-03
  • y_2025, m_8, d_27, h_4
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Aldehyde dehydrogenase 1-L1/ALDH1L1 抗体 (YY8) is rated 4.1 out of 5 by 7.
  • y_2025, m_8, d_27, h_4
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