Date published: 2025-9-7

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Adducin γ 抗体 (D-11): sc-365178

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说明书
  • Adducin γ抗体(D-11)是小鼠单克隆IgG3 κ, 在2篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Adducin γ的C-terminus附近的氨基酸631-657之间
  • 推荐用于 mouse, rat 和 human 来源的Adducin γ WB, IP, IF 和 ELISA检测
  • 关于如何获取Adducin γ (D-11): sc-365178免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP是Adducin γ Antibody (D-11) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与Adducin γ Antibody (D-11) 搭配使用(请参阅下面的订购信息)。

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Adducin γ 抗体(D-11)是一种 IgG3 κ 小鼠单克隆 Adducin γ 抗体,能够通过 WB、IP、IF 和 ELISA 方法检测小鼠、大鼠和人类来源的 Adducin γ。Adducin γ 抗体(D-11)以非共轭抗 Adducin γ 抗体的形式提供。Adducins 是由三个基因(α、β、γ)编码的一类细胞骨架蛋白。Adducin 是一种与质膜内小叶相关的蛋白质,也是膜骨架血影蛋白-肌动蛋白连接处定位的蛋白质之一。在细胞凋亡过程中,皮质肌动蛋白细胞骨架网络会丢失,而 Adducins 在皮质肌动蛋白网络组织中起核心作用。Adducin α 是一种细胞骨架蛋白,参与肾小管中的钠泵活动,并与高血压相关。与 Adducin β 的受限表达相比,Adducin α 和 Adducin γ 的表达无处不在。在人类中,Adducin β 在大脑和造血组织(如骨髓)中高水平表达,而在小鼠中则在脾脏中高水平表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Adducin γ 抗体 (D-11) 参考文献:

  1. 靶向干扰 beta adducin 基因(Add2)会导致小鼠红细胞球形细胞增多症。  |  Gilligan, DM., et al. 1999. Proc Natl Acad Sci U S A. 96: 10717-22. PMID: 10485892
  2. 正常血压双胞胎的血压与α-胰岛素基因座存在缔合作用,但缺乏关联性。  |  Busjahn, A., et al. 1999. J Hypertens. 17: 1437-41. PMID: 10526904
  3. α-胰高血糖素多态性与血压和心肌梗死风险的关系。  |  Psaty, BM., et al. 2000. J Hum Hypertens. 14: 95-7. PMID: 10723114
  4. 在顺铂诱导的肾上皮细胞凋亡过程中,caspase-3先在Asp-Asp-Ser-Asp633-Ala处对肌动蛋白盖蛋白α-adducin进行裂解,然后在丝氨酸726上对其进行磷酸化。  |  van de Water, B., et al. 2000. J Biol Chem. 275: 25805-13. PMID: 10823823
  5. 轻度球形红细胞遗传性椭圆形细胞增多症和β-adducin缺陷小鼠体内α-和γ-adducins水平的改变  |  Muro, AF., et al. 2000. Blood. 95: 3978-85. PMID: 10845937
  6. β-adducin(Add2)KO 小鼠表现出突触可塑性、运动协调性和行为缺陷,同时伴随着α-和γ-adducin 亚基表达和磷酸化水平的变化。  |  Porro, F., et al. 2010. Genes Brain Behav. 9: 84-96. PMID: 19900187
  7. γ-Adducin能促进过程生长和分泌蛋白从高尔基体中排出。  |  Lou, H., et al. 2013. J Mol Neurosci. 49: 1-10. PMID: 22706708
  8. γ-Adducin突变会损害肾血流的自动调节并促进肾脏疾病的发生  |  Fan, F., et al. 2020. J Am Soc Nephrol. 31: 687-700. PMID: 32029431
  9. ADD3变体引起的表现为脑瘫的遗传性痉挛性截瘫,果蝇γ-adducin模型提供了机理启示。  |  Sanchez Marco, SB., et al. 2022. Clin Genet. 102: 494-502. PMID: 36046955
  10. 蛋白激酶 C 底物的相互作用克隆。  |  Chapline, C., et al. 1993. J Biol Chem. 268: 6858-61. PMID: 8463212
  11. Rabphilin-3A:突触囊泡交通的多功能调节器。  |  Burns, ME., et al. 1998. J Gen Physiol. 111: 243-55. PMID: 9450942
  12. 肾脏肿瘤进展过程中α-和γ-adducin的重新分布和蛋白激酶C介导的磷酸化增强。  |  Fowler, L., et al. 1998. Cell Growth Differ. 9: 405-13. PMID: 9607561

订购信息

产品名称产品编号规格价格数量收藏夹

Adducin γ 抗体 (D-11)

sc-365178
200 µg/ml
$316.00

Adducin γ (D-11): m-IgG3 BP-HRP 套装

sc-550566
200 µg Ab; 40 µg BP
$354.00

Adducin γ (D-11) 中和勝肽

sc-365178 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-365178 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from we did WB for human and mouse celllysateswe did WB for human and mouse celllysates- work well, although one should use very small dilution of the Antibody. we got good IF in human HDMEC
Date published: 2015-07-14
Rated 5 out of 5 by from Robust positive signal observed in WB inRobust positive signal observed in WB in mouse Adducin transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-07-09
Rated 5 out of 5 by from Published data for WB and IF in human HaCaTPublished data for WB and IF in human HaCaT and keratinocytes. -SCBT Publication Review
Date published: 2015-05-26
Rated 5 out of 5 by from StrongStrong, specific band detected in WB in F9, HeLa and K-562 whole cell lysates. -SCBT QC
Date published: 2015-04-23
Rated 5 out of 5 by from Great immunofluorescence membrane stainingGreat immunofluorescence membrane staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-04-13
Rated 5 out of 5 by from Published data for IF in human myocardialPublished data for IF in human myocardial endothelial (MyEnd) cells. -SCBT Publication Review
Date published: 2015-02-14
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Adducin γ 抗体 (D-11) is rated 5.0 out of 5 by 6.
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