Molecular structure of Adapalene, CAS Number: 106685-40-9
Adapalene (CAS 106685-40-9)
See product citations (2)
Application:
Adapalene is a retinoic acid analog and apoptosis inducer
CAS Number:
106685-40-9
Purity:
≥99%
Molecular Weight:
412.52
Molecular Formula:
C28H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Retinoic acid analog that is a RARβ and RARγ agonist (AC50 values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cell in vitro. Displays comedolytic activity.
Adapalene (CAS 106685-40-9) References
- Adapalene: an update on newer comparative studies between the various retinoids. | Millikan, LE. 2000. Int J Dermatol. 39: 784-8. PMID: 11095202
- Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial. | Kang, S., et al. 2003. J Am Acad Dermatol. 49: 83-90. PMID: 12833014
- The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. | Ocker, M., et al. 2003. Int J Cancer. 107: 453-9. PMID: 14506747
- Clinical efficacy of adapalene (differin(®)) 0.3% gel in Chilean women with cutaneous photoaging. | Herane, MI., et al. 2012. J Dermatolog Treat. 23: 57-64. PMID: 22007702
- Recent advances in the use of adapalene 0.1%/benzoyl peroxide 2.5% to treat patients with moderate to severe acne. | Leyden, J. 2016. J Dermatolog Treat. 27 Suppl 1: S4-13. PMID: 26947815
- Adapalene suppressed the proliferation of melanoma cells by S-phase arrest and subsequent apoptosis via induction of DNA damage. | Li, H., et al. 2019. Eur J Pharmacol. 851: 174-185. PMID: 30836068
- Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris. | Vasanth, S., et al. 2020. AAPS PharmSciTech. 21: 61. PMID: 31915948
- Intravenously Administered, Retinoid Activating Nanoparticles Increase Lifespan and Reduce Neurodegeneration in the SOD1G93A Mouse Model of ALS. | Medina, DX., et al. 2020. Front Bioeng Biotechnol. 8: 224. PMID: 32292776
- Transformations of Aryl Ketones via Ligand-Promoted C-C Bond Activation. | Li, H., et al. 2020. Angew Chem Int Ed Engl. 59: 14388-14393. PMID: 32463551
- Recent Advances Regarding the Therapeutic Potential of Adapalene. | Rusu, A., et al. 2020. Pharmaceuticals (Basel). 13: PMID: 32872149
- Adapalene induces adipose browning through the RARβ-p38 MAPK-ATF2 pathway. | Lee, NH., et al. 2022. Arch Pharm Res. 45: 340-351. PMID: 35608792
- A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial. | Shalita, A., et al. 1996. J Am Acad Dermatol. 34: 482-5. PMID: 8609263
Inhibitor of:
DHRS3, GREB1L, HIV-1 Nef, Ichthyin, KRTAP9-2, Lce1k, RAI3, Rarres1, RGR, RPE, RXRβ2, and SPRR1A.Activator of:
CRABP-I, CRABP-II, CRBP IV, CYP26C1, Cytokeratin 16, DHRS7C, DHRS9, IRX2, Lce1k, NP60, RAR alpha, RAR beta, RAR gamma, RARα1, RARα2, Rarres1, RDH8, Retinal RX, Retinal RX2, Stra6, TIG3, TRIM34, and TRIM34B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adapalene, 10 mg | sc-203803 | 10 mg | $66.00 | |||
Adapalene, 50 mg | sc-203803A | 50 mg | $332.00 |