Date published: 2025-9-5

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ADAM12 抗体 (1G3): sc-293225

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说明书
  • ADAM12 抗体 1G3 是小鼠单克隆 IgG3 κ,ADAM12抗体, 在4篇文献中引用,规格为100 µg/ml
  • 针对部分重组蛋白,其氨基酸序列在ADAM12的human起源的208-304范围内
  • 推荐用于 mouse, rat 和 human 来源的ADAM12 WB, IP 和 ELISA检测
  • 关于如何获取ADAM12 (1G3): sc-293225免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成ADAM12 抗体 (1G3)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

ADAM12抗体(1G3)是一种小鼠单克隆IgG3 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的ADAM12蛋白。抗ADAM12抗体(1G3)以非结合形式提供。ADAM12蛋白(也称为Meltrin-alpha)通过促进细胞与细胞以及细胞与基质的相互作用,在包括受精和肌肉融合在内的各种生物过程中发挥着至关重要的作用。ADAM12单克隆抗体(1G3)有助于研究蛋白质在调节Notch和Delta神经源性功能方面的作用,而Notch和Delta对于发育过程中正常的细胞信号传导至关重要。ADAM12在多种组织中表达,包括大脑、睾丸、卵巢和肌肉,并存在两种不同的剪接异构体:分泌型(ADAM12S)和膜结合型(ADAM12L)。这些异构体在生理过程中具有不同的功能,例如卵子与精子的融合,这凸显了ADAM12在生殖生物学中的重要性。ADAM12 (1G3) 抗体是研究人员在研究 ADAM 蛋白在健康和疾病中的复杂作用时的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ADAM12 抗体 (1G3) 参考文献:

  1. 含分解蛋白样和金属蛋白酶的 ADAM 家族的结构-功能分析(综述)。  |  Stone, AL., et al. 1999. J Protein Chem. 18: 447-65. PMID: 10449042
  2. ADAM 基因家族:具有粘附和蛋白酶活性的表面蛋白。  |  Primakoff, P. and Myles, DG. 2000. Trends Genet. 16: 83-7. PMID: 10652535
  3. ADAM12 在健康和疾病中的细胞作用。  |  Kveiborg, M., et al. 2008. Int J Biochem Cell Biol. 40: 1685-702. PMID: 18342566
  4. ADAM12-L 是乳腺癌 miR-29 和 miR-200 家族的直接靶标。  |  Duhachek-Muggy, S. and Zolkiewska, A. 2015. BMC Cancer. 15: 93. PMID: 25886595
  5. 低氧诱导因子依赖性 ADAM12 的表达介导了乳腺癌的侵袭和转移。  |  Wang, R., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33952697
  6. FOXC2/ADAM12依赖性头颈部鳞状细胞癌细胞的放射敏感性。  |  Jing, Z., et al. 2022. Head Neck. 44: 212-225. PMID: 34731528
  7. ADAM12 是肝癌不良预后的独立预测因子。  |  Du, S., et al. 2022. Sci Rep. 12: 6634. PMID: 35459884
  8. ADAM12 可促进肺腺癌细胞对表皮生长因子受体-TKI 的耐药性,并通过激活 PI3K/Akt/mTOR 和 RAS 信号通路调节免疫微环境。  |  Li, K., et al. 2023. Int Immunopharmacol. 122: 110580. PMID: 37418984
  9. 消耗慢循环 PDGFRα+ADAM12+ 间充质细胞可通过限制巨噬细胞的排泄促进抗肿瘤免疫。  |  Di Carlo, SE., et al. 2023. Nat Immunol. 24: 1867-1878. PMID: 37798557
  10. 一种参与肌母细胞融合的金属蛋白酶-二整合蛋白。  |  Yagami-Hiromasa, T., et al. 1995. Nature. 377: 652-6. PMID: 7566181
  11. ADAM,一种含有崩解蛋白和金属蛋白酶结构域的新型膜蛋白家族:在细胞-细胞和细胞-基质相互作用中具有多种潜在功能。  |  Wolfsberg, TG., et al. 1995. J Cell Biol. 131: 275-8. PMID: 7593158
  12. 一种新型分泌型人类 ADAM 12(meltrin alpha)可促进体内肌生成。  |  Gilpin, BJ., et al. 1998. J Biol Chem. 273: 157-66. PMID: 9417060

订购信息

产品名称产品编号规格价格数量收藏夹

ADAM12 抗体 (1G3)

sc-293225
100 µg/ml
$316.00

Is it possible to obtain the 1G3 antibody sequence?

Asked by: Orit
Thank you for your question. The sequence is proprietary.
Answered by: BlakeJ
Date published: 2023-03-16

ADAM12 抗体 (1G3): sc-293225,是否可以偶联荧光基团?

Asked by: dengchch
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Gibt es zu dem Antikörper eine Liste von sicheren Positiv -und Negativkontrollen in spezifischen Geweben? Es wäre sehr hilfreich um den AK korrekt zu validieren.

Asked by: CarlottaKE
Vielen Dank für Ihre Frage. Leider gibt es nur wenige Daten zu der Expression von ADAM12. Ein Gewebe für das starke Expression von ADAM12 beschrieben ist, ist humanes Plazentagewebe. Der Antikörper wurde in unseren Labors mit ADAM12-transfizierten HEK293T-Zelllysaten etabliert. Untransfizierte HEK293T Zellen exprimieren das Protein nicht und wurden als Negativkontrolle verwendet. Bitte kontaktieren Sie unseren technichschen Service wenn Sie weitere Fragen haben sollten. "Is there a list of positive and negative control tissues for this antibody?" Thank you for your question. Unfortunately, there is only little data regarding the expression of ADAM12. Robust expression of ADAM12 has been described for human placental tissue. We have established this antibody using ADAM12-transfected HEK293T whole cell lysates. Untransfected HEK293T cells do not express the protein and were used as negative controls. Please contact our technical service if you have further questions.
Answered by: Technical Support Europe
Date published: 2019-01-15

For Western Blot, is it recommended to use denatured or non-denatured conditions with ADAM12 (1G3): sc-293225 antibody?

Asked by: AbPolly
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
  • y_2025, m_8, d_27, h_5CST
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Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with MDA-MB-231, MDA-MB-468, T47D, and BT-474 cell lysates in published research -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from 有主要检测的条带之前申请了试用装,用来做westernblot能检测出好几个条带。这也跟这个蛋白有几个不同的形式有关吧。推荐使用。
Date published: 2017-07-05
Rated 4 out of 5 by from 条带单一,非常好之前订购了试用装,用作WB,条带明显,符合试验检测要求. 条件1:1000稀释,用作结直肠癌细胞系蛋白的检测
Date published: 2017-03-17
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ADAM12 抗体 (1G3) is rated 4.3 out of 5 by 3.
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