Molecular structure of Acipimox, CAS Number: 51037-30-0
Acipimox (CAS 51037-30-0)
Alternate Names:
5-CARBOXY-2-METHYLPYRAZINE 1-OXIDE; Olbetam
Application:
Acipimox is a hypolipidaemic agent that is more potent than nicotinic acid and clofibrate
CAS Number:
51037-30-0
Purity:
≥95%
Molecular Weight:
154.12
Molecular Formula:
C6H6N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acipimox is a chemical compound that functions as a potent inhibitor of lipolysis and triglyceride synthesis. It acts by inhibiting the enzyme lipoprotein lipase, which plays a role in the hydrolysis of triglycerides from circulating lipoproteins. By blocking this enzyme, acipimox effectively reduces the release of free fatty acids from adipose tissue and decreases the synthesis of triglycerides in the liver. This mechanism of action results in a decrease in plasma triglyceride levels and an increase in high-density lipoprotein cholesterol levels. Acipimox may enhance insulin sensitivity in peripheral tissues, contributing to its impact on lipid metabolism. Acipimox′s mode of action involves the inhibition of key enzymes involved in lipid metabolism, leading to alterations in plasma lipid levels and insulin sensitivity.
Acipimox (CAS 51037-30-0) References
- Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed mice. | Ahrén, B. 2001. Acta Physiol Scand. 171: 161-7. PMID: 11350276
- Acipimox stimulates leptin production from isolated rat adipocytes. | Wang-Fisher, YL., et al. 2002. J Endocrinol. 174: 267-72. PMID: 12176665
- Molecular identification of high and low affinity receptors for nicotinic acid. | Wise, A., et al. 2003. J Biol Chem. 278: 9869-74. PMID: 12522134
- Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. | Jung, JK., et al. 2007. J Med Chem. 50: 1445-8. PMID: 17358052
- Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36. | Ma, S., et al. 2011. Lipids Health Dis. 10: 53. PMID: 21486455
- Acipimox-enhanced ¹⁸F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model. | Bousquenaud, M., et al. 2012. Int J Cardiovasc Imaging. 28: 1407-15. PMID: 22116590
- Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet. | Jin, F., et al. 2012. Biochem Biophys Res Commun. 428: 86-92. PMID: 23058919
- Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms. | Zhou, E., et al. 2014. Int Immunopharmacol. 23: 121-6. PMID: 25038318
- Free fatty acids, not triglycerides, are associated with non-alcoholic liver injury progression in high fat diet induced obese rats. | Liu, J., et al. 2016. Lipids Health Dis. 15: 27. PMID: 26868515
- Inhibition of Lipolysis With Acipimox Attenuates Postburn White Adipose Tissue Browning and Hepatic Fat Infiltration. | Barayan, D., et al. 2020. Shock. 53: 137-145. PMID: 31425403
- Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner. | Yan, Y., et al. 2020. Redox Biol. 37: 101742. PMID: 33045621
- Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia. | Shen, X., et al. 2022. Molecules. 27: PMID: 36234950
- Evaluation of the lipid-lowering activity of AY-25,712 in rats. | Cayen, MN., et al. 1982. Atherosclerosis. 45: 267-79. PMID: 6818976
- Hypolipidemic 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids. | Jirkovsky, I. and Cayen, MN. 1982. J Med Chem. 25: 1154-6. PMID: 7143351
- Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes. | Christie, AW., et al. 1996. Diabetologia. 39: 45-53. PMID: 8720602
Inhibitor of:
apoA-V, CIDE-B, DECR2, DSCD75, FIT1, and HM74B.Activator of:
EHHADH, FATP4, HM74A, HM74B, and pan 14-3-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acipimox, 50 mg | sc-203497 | 50 mg | $79.00 | |||
Acipimox, 100 mg | sc-203497A | 100 mg | $131.00 |