Date published: 2026-5-7

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ABT-491 hydrochloride (CAS 189689-94-9)

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Alternate Names:
A-137491
Application:
ABT-491 hydrochloride is a highly potent and selective PAF-R antagonist
CAS Number:
189689-94-9
Purity:
≥98%
Molecular Weight:
515.97
Molecular Formula:
C28H22FN5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ABT-491 hydrochloride is a compound that is often used in biochemical research to explore its binding affinity and inhibition properties towards various enzyme targets. Researchers study ABT-491 hydrochloride to understand its structure-activity relationships in the context of enzyme inhibition, which can provide valuable insights into enzyme kinetics and dynamics. The compound is also used in the investigation of signaling pathways, where its ability to modulate specific enzymes can influence the pathway outcomes. In addition, ABT-491 hydrochloride is of interest in the field of chemistry for the synthesis of analogs and derivatives that could have different or improved properties. Its role in such studies is for advancing knowledge in enzyme regulation and for the potential design of new compounds with specific biochemical activities.


ABT-491 hydrochloride (CAS 189689-94-9) References

  1. Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor.  |  Xu, Z., et al. 2010. Mol Ther. 18: 609-16. PMID: 19953082
  2. Polyinosine-polycytidylic acid enhances cellular adherence of Streptococcus pneumoniae.  |  Kawabata, M. and Kurono, Y. 2011. Laryngoscope. 121: 2443-8. PMID: 21994002
  3. Structural and vibrational properties of imidazo[4,5-c]pyridine, a structural unit in natural products.  |  Dymińska, L., et al. 2013. J Nat Prod. 76: 1637-46. PMID: 24070053
  4. Imidazopyridines as a source of biological activity and their pharmacological potentials-Infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials.  |  Dymińska, L. 2015. Bioorg Med Chem. 23: 6087-99. PMID: 26314922
  5. The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis.  |  Albert, DH., et al. 1998. J Pharmacol Exp Ther. 284: 83-8. PMID: 9435164

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ABT-491 hydrochloride, 5 mg

sc-214459
5 mg
$307.00

ABT-491 hydrochloride, 25 mg

sc-214459A
25 mg
$1144.00

is this product in stock? I want to know before I make the order

Asked by: Anonymous
Thank you for contacting Santa Cruz Biotechnology. For a price quote and ship date please email scbt@scbt.com.
Answered by: BlakeJ
Date published: 2026-02-26
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Rated 5 out of 5 by from BozluBozlu, G. et al. (PubMed 17320823) reported that platelet-activating factor antagonist (ABT-491) decreased neuronal apoptosis in a neonatal rat model of hypoxic ischemic brain injury. -SCBT Publication Review
Date published: 2015-02-25
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ABT-491 hydrochloride is rated 5.0 out of 5 by 1.
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