Molecular structure of 5α-Pregnane-3α,20α-diol, CAS Number: 566-58-5
5α-Pregnane-3α,20α-diol (CAS 566-58-5)
Application:
5α-Pregnane-3α,20α-diol is A progesterone metabolite
CAS Number:
566-58-5
Molecular Weight:
320.51
Molecular Formula:
C21H36O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5α-Pregnane-3α,20α-diol is a progesterone metabolite. It is a C21 steroid hormone found in many species, including humans. It has been studied for its role in stress, metabolism, and reproductive physiology. It has also been shown to have anti-inflammatory, anti-oxidant, and anti-cancer effects.
5α-Pregnane-3α,20α-diol (CAS 566-58-5) References
- Quantitative changes in the metabolism of 20alpha-hydroxy-4-pregnen-3-one by rat hypothalamus and pituitary during proestrus. | Nowak, FV., et al. 1976. Steroids. 28: 509-20. PMID: 1034357
- Progesterone metabolism in the ovaries and testes of the echinoid Lytechinus variegatus Lamarck (Echinodermata). | Wasson, KM. and Watts, SA. 2000. Comp Biochem Physiol C Toxicol Pharmacol. 127: 263-72. PMID: 11246497
- Physiological variations in the ovarian production of 5alpha-pregnane derivatives with sedative properties in the rat. | Holzbauer, M. 1975. J Steroid Biochem. 6: 1307-10. PMID: 1181486
- 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate. | Wilson, JD., et al. 2003. Endocrinology. 144: 575-80. PMID: 12538619
- The steroidogenic characteristics of primary testicular cell cultures from adult hypophysectomized rats: enhanced formation of C21 steroids. | Payne, DW., et al. 1988. Biol Reprod. 39: 581-91. PMID: 3196792
- Secretion of pregnane compounds from polycystic ovaries of androgen-sterilized rats. | Sawada, T. 1986. Steroids. 48: 259-66. PMID: 3445281
- Ovarian secretion of pregnane compounds at first ovulation in rats treated with pregnant mare's serum gonadotropin. | Sawada, T. 1986. Steroids. 47: 327-35. PMID: 3590243
- Effects on gonadotropin secretion of 5-alpha-pregnane-3 alpha, 20 alpha-diol, a physiological progesterone derivative. | Zanisi, M. and Martini, L. 1979. Proc Soc Exp Biol Med. 161: 66-9. PMID: 441072
- Conversion of 20alpha-hydroxy-4-pregnen-3-one to 20alpha-hydroxy-5alpha-pregnan-3-one and 5alpha-pregnane-3alpha, 20alpha-diol by rat anterior pituitary. | Nowak, FV. and Karavolas, HJ. 1974. Steroids. 24: 351-7. PMID: 4472042
- Induction of lordosis behavior in female rats by intravenous administration of progestins. | Kubli-Garfias, C. and Whalen, RE. 1977. Horm Behav. 9: 380-6. PMID: 611085
- Differential actions of FSH and androgens on progesterone catabolism by rat granulosa cells. | Moon, YS., et al. 1984. Biochem Biophys Res Commun. 119: 694-9. PMID: 6424669
- In vitro metabolism of progesterone in the mammary tumor and the normal mammary gland of GRS/A strain of mice and dependency of some steroid-metabolizing enzyme activities upon ovarian function. | Mori, M. and Tamaoki, BI. 1980. Eur J Cancer (1965). 16: 185-93. PMID: 6929251
- Pre-ovulatory changes in steroidogenesis in ovaries from immature rats treated with pregnant mare serum gonadotrophin. | Eckstein, B., et al. 1976. J Endocrinol. 70: 485-90. PMID: 978107
Inhibitor of:
CH25H.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5α-Pregnane-3α,20α-diol, 5 mg | sc-207076A | 5 mg | $274.00 | |||
5α-Pregnane-3α,20α-diol, 10 mg | sc-207076 | 10 mg | $352.00 | |||
5α-Pregnane-3α,20α-diol, 25 mg | sc-207076B | 25 mg | $699.00 |