5,7-Dichloro-8-quinolinol (CAS 773-76-2)

物理状态 :

Solid

溶解度 :

5% IN DIOXANE; CLEAR TO SLIGHTLY HAZY,YELLOW OR GREEN SOLUTION.Soluble in benzene, acetone. Slightly soluble in acetic acid. Readily soluble in sodium and potassium hydroxides and in acids, forming solutions. Very slightly soluble in: Ethanol Chloroform.

保存 :

Store at room temperature

熔点 :

178-180° C (lit.)

沸点 :

~354.7° C at 760 mmHg (Predicted)

密度 :

~1.5 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.70 (Predicted)

IC50 :

Arachidonate 5-lipoxygenase: IC₅₀ = 3.6 µM (human); Arachidonate 12-lipoxygenase: IC₅₀ = 1.9 µM (human); Arachidonate 15-lipoxygenase, type II: IC₅₀ = 28 µM (human); Arachidonate 15-lipoxygenase: IC₅₀ = 2.4 µM (human); Kappa opioid receptor: IC₅₀ = 4.56 µM (human); Streptococcus sp. ′group A′: EC₅₀50 = 258 nM (Streptococcus sp. ′group A′); Streptococcus: EC₅₀50 = 3306 nM (Streptococcus); Beta-galactosidase: EC₅₀50 = >31.5 µM (Escherichia coli); Streptokinase A: EC₅₀50 = 148 nM (Streptococcus pyogenes serotype M1); Delta opioid receptor: IC₅₀ >32 µM (human)

pK值 :

pK_a: 2.30, pK_b: 7.20

德国水公害等级 :

3

RTECS :

VC5350000

PubChem CID :

Merck 索引 :

14: 2175

MDL 号码 :

MFCD00006786

EC号码 :

212-258-3

Beilstein 注册 :

153606

SMILES :

C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1