4-Hydroxyphenylretinamide CAS: 65646-68-6
MF: C26H33NO2
MW: 391.55
An agonist displaying activity at retinoid receptors.

4-Hydroxyphenylretinamide (CAS 65646-68-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 145ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
同义词: Retinoic acid p-hydroxyanilide; Fenretinide; 4-HPR
应用; An agonist displaying activity at retinoid receptors
CAS号码: 65646-68-6
分子量: 391.55
分子式: C26H33NO2
* 参考分析证明 大量特定数据 (包括水 含量).
提交对此产品的评价,获得15个CruzCredits

4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all trans retinoic acid, which displays antiproliferative effects on cultured human breast cancer cells. In addition, 4-Hydroxyphenylretinamide functions as a selective activator of RAR (retinoid receptors). Studies involving lymphoid and myeloid malignant cell lines indicate that 4-Hydroxyphenylretinamide can induce apoptosis and reduce cell growth. These studies suggest that 4-Hydroxyphenylretinamide and all trans retanoic acid may bind to two different receptors to induce apoptosis.


参考文献

1. Marth, C., et al. 1985. J. Natl. Cancer Inst. 75: 871-875. PMID: 2932587
2. Grubbs, C.J., et al. 1990. Anticancer Res. 10: 661-666. PMID: 2142393
3. Delia, D., et al. 1993. Cancer Res. 53: 6036-6041. PMID: 8261419
4. Ponzoni, M., et al. 1995. Cancer Res. 55: 853-861. PMID: 7850799
5. Fanjul, A.N., et al. 1996. J. Biol. Chem. 271: 22441-22446. PMID: 8798408

物理状态 :
Solid
溶解度 :
Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml)), chloroform, and acetone (easily soluble).
保存 :
Store at -20° C
折射率 :
n20D 1.61
IC50 :
MDA-MB-231 (Breast adenocarcinoma cells): IC50 = 7700 (human); MCF7 (Breast carcinoma cells): IC50 = 150 (human); PC-3 (Prostate carcinoma cells): IC50 = 3600 (human); LNCaP (Prostate carcinoma): IC50 = 7500 (human)
Ki 数据 :
Retinoic acid receptor gamma: Ki= >400 nM (human); Retinoid X receptor alpha: Ki= >2200 nM (human); Retinoid X receptor beta: Ki= >2800 nM (human); Retinoid X receptor gamma: Ki= >6000 nM (human)
pK值 :
pKa: 9.98, pKb: 1.55
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
VH6420000
PubChem CID :
5288209
默克索引 :
14: 3998
MDL 号码 :
MFCD00792674
SMILES :
CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)NC2=CC=C(C=C2)O)C)C

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话1-800-457-3801。 版权 ©, 2007-2020圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。