3-Sulfoglycolithocholic Acid Disodium Salt (CAS 64936-82-9)

3-Sulfoglycolithocholic Acid Disodium Salt is a bile acid derivative characterized by the presence of both sulfate and glycolate groups attached to the lithocholic acid backbone, further modified by the addition of two sodium ions to enhance its solubility in aqueous solutions. This compound plays a pivotal role in research focused on understanding the complex mechanisms underlying bile acid metabolism, transport, and signaling pathways. Specifically, its unique structure allows for the investigation of the sulfation process—a modification that significantly alters bile acid′s physicochemical properties and interactions with bile salt transporters. By acting as a selective tool in experimental applications, 3-Sulfoglycolithocholic Acid Disodium Salt aids in elucidating the intricate balance between hydrophobicity and hydrophilicity in bile acids, which is essential for maintaining cholesterol homeostasis and lipid digestion. Furthermore, its application in studies offers insights into the regulation of enterohepatic circulation and the role of bile acids in liver diseases, thereby contributing to the broader understanding of hepatic function and gastrointestinal health.