2′-C-Methyladenosine (CAS 15397-12-3)
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2′-C-Methyladenosine (2′-CMA) is a modified nucleoside present in eukaryotic mRNA, serving as a element in RNA metabolism, gene expression, and regulation. It represents a modified version of adenosine and is prevalent in the mRNA of various organisms, including humans. 2′-C-Methyladenosine assumes a significant role in gene expression regulation and contributes to cellular development and functionality by participating in diverse biochemical and physiological processes. Although the precise mechanism of action of 2′-C-Methyladenosine remains incompletely understood, it is believed to engage with ribosomes, thereby exerting influence on mRNA stability, translation, and splicing. Moreover, it is implicated in the regulation of protein synthesis and mRNA processing, augmenting its impact on gene expression regulation. In addition to its regulatory role, 2′-C-Methyladenosine has demonstrated the ability to impede HCV RNA replication without inducing cytotoxicity. In vitro experiments have revealed that the corresponding triphosphates act as potent, competitive inhibitors of NS5B-catalyzed reactions.
2′-C-Methyladenosine (CAS 15397-12-3) References
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- Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection. | Hecker, SJ., et al. 2007. J Med Chem. 50: 3891-6. PMID: 17636948
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′-C-Methyladenosine, 50 mg | sc-283467 | 50 mg | $204.00 | |||
2′-C-Methyladenosine, 100 mg | sc-283467A | 100 mg | $380.00 | |||
2′-C-Methyladenosine, 1 g | sc-283467B | 1 g | $662.00 |