13-cis-Retinoic acid (CAS 4759-48-2)

5.0(1)

写一个评价提问

查看产品引用文献(7)

备用名: Isotretinoin; Accutane; Amnesteem; Claravis

应用； 13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation

CAS号码: 4759-48-2

纯度: ≥98%

分子量: 300.44

分子式: C₂₀H₂₈O₂

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

快捷链接

点击图片或放大按钮来放大

13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. Clinically, 13-cis-Retinoic acid is primarily used in the treatment of severe recalcitrant nodular acne. Its effects include reducing the production of sebum, shrinking the size of the sebaceous glands, stabilizing keratinization, preventing comedones from forming, and reducing inflammation of inflammatory acne. Though the exact mechanism of action of 13-cis-Retinoic acid is not fully understood, studies have suggested that the compound alters DNA transcription and induces apoptosis in select types of cells throughout the body.

参考文献

1. Samokyszyn, V.M., et al. 1987. J. Biol. Chem. 262: 14119-14133. PMID: 3115987
2. Samokyszyn, V.M., et al. 1997. Chem. Res. Toxicol. 10: 795-801. PMID: 9250414
3. Chang, H.C., et al. 2000. Kaohsiung J. Med. Sci. 16: 387-392. PMID: 11221542

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in chloroform (50 mg/ml), DMSO (60 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (25 mg/ml), and ether (sparingly).

保存 :

Store at -20° C

熔点 :

172-175° C (lit.)

沸点 :

~462.80° C at 760 mmHg (Predicted)

密度 :

1.01 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.56 (Predicted)

IC50 :

ERK 2: IC₅₀ = 0.46 µM (human); SR-2B: IC₅₀ = 0.85 µM (human); Cellular retinoic acid-binding protein I: IC₅₀ = 0.9 µM (red junglefowl); Retinoic acid receptor α: IC₅₀ >1 µM (mouse); Retinoic acid receptor γ: IC₅₀ >1 µM (mouse)

Ki 数据 :

SR-2B: K_i= 0.54 µM (human); Adenosine A3-R: K_i= 2.36 µM (human); α2B-AR: K_i= 3.02 µM (human); Dictyostelium discoideum AX2 RNase P: K_i= 20 µM

pK值 :

pK_a: 4.76 (Predicted)

仅供科研使用。不可用于诊断或治疗。

德国水公害等级 :

RTECS :

VH6440000

PubChem CID :

5282379

默克索引 :

14: 5228

MDL 号码 :

MFCD00079542

EC号码 :

225-296-0

Beilstein 注册 :

1885770

SMILES :

CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\\C(=O)O)/C)/C

下载SDS

分析证明书

在PDF文件上阅读，打印和批注，Adobe阅读器是必须的