Molecular structure of 10-Hydroxygeraniol, CAS Number: 26488-97-1
10-Hydroxygeraniol (CAS 26488-97-1)
Alternate Names:
(E,E)-2,6-Dimethyl-2,6-octadiene-1,8-diol; (E,E)-2,6-Dimethylocta-2,6-diene-1,8-diol
Application:
10-Hydroxygeraniol is a substrate for 8-hydroxygeraniol dehydrogenase
CAS Number:
26488-97-1
Molecular Weight:
170.25
Molecular Formula:
C10H18O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
10-Hydroxygeraniol is a monoterpene which is synthesized from geraniol. 10-Hydroxygeraniol is a substrate for 8-hydroxygeraniol dehydrogenase (G80) and is a step in the synthesis of the secologanin which is a key monoterpene needed for formation of terpene indole alkaloids. Moreover, (6E)-8-hydroxygeraniol has been investigated for its ability to combat oxidative stress.
10-Hydroxygeraniol (CAS 26488-97-1) References
- Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures. | Morgan, JA. and Shanks, JV. 2000. J Biotechnol. 79: 137-45. PMID: 10812182
- Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis. | Collu, G., et al. 2001. FEBS Lett. 508: 215-20. PMID: 11718718
- Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots. | Hong, SB., et al. 2003. Biotechnol Prog. 19: 1105-8. PMID: 12790690
- Transient effects of overexpressing anthranilate synthase alpha and beta subunits in Catharanthus roseus hairy roots. | Peebles, CA., et al. 2005. Biotechnol Prog. 21: 1572-6. PMID: 16209565
- Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell cultures. | Lee-Parsons, CW. and Royce, AJ. 2006. Plant Cell Rep. 25: 607-12. PMID: 16432630
- Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols. | Ikeda, H., et al. 1991. J Biochem. 109: 341-7. PMID: 1864846
- Cell-specific expression of tryptophan decarboxylase and 10-hydroxygeraniol oxidoreductase, key genes involved in camptothecin biosynthesis in Camptotheca acuminata Decne (Nyssaceae). | Valletta, A., et al. 2010. BMC Plant Biol. 10: 69. PMID: 20403175
- Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch. | Wang, J., et al. 2010. Biosci Biotechnol Biochem. 74: 1583-90. PMID: 20699579
- Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid. | Sung, PH., et al. 2011. J Agric Food Chem. 59: 4637-43. PMID: 21504162
- Characterization of 10-hydroxygeraniol dehydrogenase from Catharanthus roseus reveals cascaded enzymatic activity in iridoid biosynthesis. | Krithika, R., et al. 2015. Sci Rep. 5: 8258. PMID: 25651761
- Engineering of a Nepetalactol-Producing Platform Strain of Saccharomyces cerevisiae for the Production of Plant Seco-Iridoids. | Campbell, A., et al. 2016. ACS Synth Biol. 5: 405-14. PMID: 26981892
- Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus. | Sandholu, AS., et al. 2020. Proteins. 88: 1197-1206. PMID: 32181958
- Characterization of Camptotheca acuminata 10-hydroxygeraniol oxidoreductase and iridoid synthase and their application in biological preparation of nepetalactol in Escherichia coli featuring NADP+ - NADPH cofactors recycling. | Awadasseid, A., et al. 2020. Int J Biol Macromol. 162: 1076-1085. PMID: 32599240
- Cytochrome P-450LM2 mediated hydroxylation of monoterpene alcohols. | Licht, HJ. and Coscia, CJ. 1978. Biochemistry. 17: 5638-46. PMID: 728422
- Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa). | Hallahan, DL., et al. 1995. Arch Biochem Biophys. 318: 105-12. PMID: 7726550
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10-Hydroxygeraniol, 25 mg | sc-489619 | 25 mg | $380.00 |