1-Methyluric acid (CAS 708-79-2)
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1-Methyluric acid is a compound that features prominently in research focused on purine metabolism, an area of particular interest in cellular biochemistry. As a metabolite in the breakdown pathway of caffeine, it serves as a useful biomarker for studying the metabolism and biological effects of methylxanthines. Researchers employ 1-methyluric acid to analyze the enzymatic processes involved in the degradation of adenosine derivatives, which are important in understanding energy transfer and the regulation of neurological activity. Additionally, this compound is used in analytical studies to develop and refine detection methods for metabolite profiling, facilitating the exploration of metabolic responses to dietary and environmental factors.
1-Methyluric acid (CAS 708-79-2) References
- Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. | Kuh, HJ. and Shim, CK. 1994. Arch Pharm Res. 17: 124-30. PMID: 10319144
- Improved HPLC assay for measuring serum vitamin C with 1-methyluric acid used as an electrochemically active internal standard. | McCoy, LF., et al. 2005. Clin Chem. 51: 1062-4. PMID: 15860567
- An unusual patient with kidney stones composed of 1-methyluric acid. | Davies, PM., et al. 2006. Urol Res. 34: 58-60. PMID: 16397778
- Caffeine acetylator phenotyping during maturation in infants. | Pariente-Khayat, A., et al. 1991. Pediatr Res. 29: 492-5. PMID: 1896253
- Uric and 1-methyluric acids: metabolic wastes or antiradical protectors? | León-Carmona, JR. and Galano, A. 2011. J Phys Chem B. 115: 15430-8. PMID: 22097927
- The effects of xanthine oxidase inhibition by febuxostat on the pharmacokinetics of theophylline. | Tsai, M., et al. 2012. Int J Clin Pharmacol Ther. 50: 331-7. PMID: 22541837
- Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. | Chae, JW., et al. 2012. Food Chem Toxicol. 50: 3666-72. PMID: 22771369
- Effect of decursin on the pharmacokinetics of theophylline and its metabolites in rats. | Chae, JW., et al. 2012. J Ethnopharmacol. 144: 248-54. PMID: 22981724
- Xanthine urolithiasis: Inhibitors of xanthine crystallization. | Grases, F., et al. 2018. PLoS One. 13: e0198881. PMID: 30157195
- 1-Methyluric Acid Nephropathy. | Zaworski, J., et al. 2020. Kidney Int Rep. 5: 737-741. PMID: 32405596
- Nonlinear theophylline elimination. | Tang-Liu, DD., et al. 1982. Clin Pharmacol Ther. 31: 358-69. PMID: 7060318
- Determination of caffeine and its metabolites in urine by high-performance liquid chromatography and capillary electrophoresis. | Rodopoulos, N. and Norman, A. 1994. Scand J Clin Lab Invest. 54: 305-15. PMID: 7939374
- Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients. | Tateishi, T., et al. 1999. Pediatr Res. 45: 66-70. PMID: 9890610
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Methyluric acid, 10 mg | sc-208662A | 10 mg | $173.00 | |||
1-Methyluric acid, 50 mg | sc-208662 | 50 mg | $525.00 |