PGBD5激活剂
PGBD5, or PiggyBac Transposable Element Derived 5, is a protein that is encoded by the PGBD5 gene in humans. As its name suggests, it's related to the piggyBac family of transposable elements, which are sequences of DNA that can move or "jump" to different positions within the genome.PGBD5 is unique because it's a domesticated transposase, meaning it's found in a transposable element that has been incorporated into the host genome and repurposed for a cellular function. This is a relatively rare event in evolution.
The specific function of PGBD5 is not completely understood. However, it's been associated with DNA repair and has been found to be overexpressed in certain types of cancers, including neuroblastoma and medulloblastoma. There's evidence that PGBD5 may contribute to genomic instability and tumorigenesis, possibly by inducing DNA rearrangements.
PGBD5 has been proposed as a biomarker for certain pediatric cancers, and it's an active area of research in cancer biology. Understanding the role of PGBD5 in tumorigenesis could provide insights into the mechanisms of cancer development and progression.
| 产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
奥拉帕利是一种 PARP 抑制剂，可间接影响 DNA 修复机制。通过抑制 PARP，它可能会改变细胞环境，从而影响 PGBD5 的活性。 | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $178.00 $270.00 $712.00 | 3 | |
Veliparib 是另一种 PARP 抑制剂。它在 DNA 修复中的作用可能会对 PGBD5 产生间接影响，尤其是在 DNA 损伤反应中。 | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Rucaparib 也是一种 PARP 抑制剂，可通过调节 DNA 修复途径和基因组稳定性来影响 PGBD5 的活性。 | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
作为一种强效 PARP 抑制剂，Talazoparib 可能会通过其在 DNA 损伤和修复中的作用来影响 PGBD5。 | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
丝裂霉素 C 是一种能形成 DNA 交联的烷化剂，因此可能会通过诱导 DNA 损伤和修复反应来影响 PGBD5 的活性。 | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
依托泊苷会干扰 DNA 拓扑异构酶 II，影响 DNA 修复和复制，从而间接调节 PGBD5。 | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
顺铂会形成 DNA 加合物，导致 DNA 损伤。这可能会间接影响 DNA 修复途径中 PGBD5 的活性。 | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
喜树碱是一种拓扑异构酶 I 抑制剂，会影响 DNA 复制和修复，从而可能间接影响 PGBD5。 | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
博莱霉素会导致 DNA 链断裂，可能会影响 DNA 损伤反应中 PGBD5 的活性。 | ||||||
Carboplatin | 41575-94-4 | sc-202093 sc-202093A | 25 mg 100 mg | $47.00 $132.00 | 14 | |
卡铂与顺铂类似，会形成 DNA 加合物，并可能通过其在 DNA 修复中的作用间接影响 PGBD5。 | ||||||