Gm13977, as a predicted gene, encodes a protein that is likely to be a crucial component in cellular signaling networks. While the specific functions of Gm13977 are not well-defined due to its status as a predicted gene, it is reasonable to hypothesize that it plays a role in processes such as signal transduction, cellular response to stimuli, and potentially in regulating gene expression. Proteins like Gm13977 are typically integral to cellular communication, acting as conduits for external signals to manifest as cellular responses. The activation of Gm13977 is presumed to be heavily reliant on post-translational modifications, especially phosphorylation, a common regulatory mechanism in cellular signaling pathways. Phosphorylation acts as a pivotal molecular switch that modifies the functional state of a protein, thereby regulating its activity and interactions with other cellular components. The proposed activators of Gm13977, as listed in the table, are believed to exert their effects by influencing the phosphorylation landscape within the cell. These chemicals target various enzymes like kinases and phosphatases, which play key roles in modulating the phosphorylation status of proteins. By inhibiting phosphatases or activating kinases, these chemicals increase the phosphorylation levels of key proteins, which could in turn enhance the functional activity of Gm13977.
Understanding the potential activation mechanisms of Gm13977 is crucial for elucidating the complex signaling networks in which it may be involved. The indirect activation of Gm13977 through these chemicals highlights the intricate interplay of phosphorylation events that regulate its activity. This knowledge is vital for comprehending the molecular basis of signal transduction processes involving Gm13977 and provides insights into its possible role in cellular physiology. As research progresses, these insights will be instrumental in uncovering the full spectrum of Gm13977's functions and its impact on cellular processes.
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产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA 作为一种蛋白激酶 C(PKC)激活剂,可以通过促进 PKC 介导的 Gm13977 信号通路中蛋白质的磷酸化来激活 Gm13977,从而增强 Gm13977 的功能活性。 | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
异诺霉素能提高细胞内的钙含量,可能通过钙依赖性激酶激活 Gm13977,从而磷酸化并激活 Gm13977 信号级联中的蛋白质。 | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin通过抑制SERCA泵增加细胞内钙离子浓度。钙离子浓度升高可通过钙离子依赖性激酶激活Gm13977,从而增强Gm13977信号网络中蛋白质的磷酸化。 | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
冈田酸抑制蛋白磷酸酶PP1和PP2A,导致蛋白质过度磷酸化。这种过度磷酸化可能会通过增强其信号通路中蛋白质的磷酸化来激活Gm13977。 | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
钙调素A抑制PP1和PP2A,导致蛋白质过度磷酸化。磷酸化水平升高可通过调节信号网络中蛋白质的磷酸化动态来激活Gm13977。 | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
安乃近能激活应激活化蛋白激酶(SAPKs)。SAPK 激活可使调节蛋白磷酸化,通过改变其信号通路中的相互作用来激活 Gm13977。 | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
双吲哚马来酰亚胺 I 是一种 PKC 抑制剂,在某些条件下可增强 PKC 信号传导。增强的 PKC 活性可能会通过磷酸化其信号轴上的蛋白质来激活 Gm13977。 | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
尽管是激酶抑制剂,但staurosporine仍可诱导蛋白质过度磷酸化。这种过度磷酸化可通过改变信号传导通路中蛋白质的磷酸化模式来激活Gm13977。 | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine 是一种 PKC 抑制剂,可能会影响 PKC 底物的动态,从而通过改变其信号网络中蛋白质的磷酸化来激活 Gm13977。 | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin 可抑制 PP1 和 PP2A,导致蛋白质磷酸化增加。这可能会通过改变其信号通路中蛋白质的磷酸化状态来激活 Gm13977。 |