The chemical class known as FGF-8F activators encompasses a variety of compounds that can influence the modulation of the FGF-8F protein's activity through their interaction with several cellular signaling pathways. These activators are primarily characterized by their ability to interfere with the intracellular signaling cascades that FGF-8F is known to be involved in, such as the MAPK, PI3K/AKT, and PLCγ pathways. The actions of these chemicals result in cellular responses that can lead to the activation of FGF-8F signaling, albeit in an indirect fashion, by triggering a complex network of regulatory mechanisms within the cell.
The chemical activators in this class typically function by inhibiting specific enzymes or kinases that are crucial components of the signaling pathways related to FGF-8F activity. This inhibition can result in the alteration of the cellular signaling environment, which can, in turn, trigger compensatory responses that activate FGF-8F signaling. These responses may include the upregulation of other signaling molecules, alteration of receptor sensitivities, or changes in the expression levels of various downstream targets. By affecting these pathways, the activators can influence the cellular processes that are governed by FGF-8F, such as cell proliferation, differentiation, and survival. The diversity of these compounds allows for the modulation of FGF-8F signaling in multiple contexts, reflecting the broad biological roles that FGF-8F plays in cellular function.
関連項目
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
---|---|---|---|---|---|---|
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 是 MAPK 通路中一种激酶 MEK 的选择性抑制剂;通过抑制 MEK,U0126 可导致激活 FGF8 信号的代偿机制。 | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
一种 PI3K 抑制剂,可破坏下游 AKT 信号传导,从而通过细胞信号反馈回路影响 FGF8 的活性。 | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
一种 PI3K 抑制剂,可改变 AKT 通路信号,并可通过改变细胞稳态激活 FGF8 信号。 | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MAPK 通路中 MEK1/2 的选择性抑制剂;通过阻断该通路,PD98059 可以改变细胞环境,从而激活 FGF8 信号。 | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR 抑制剂可影响 PI3K/AKT 信号传导,并可通过启动细胞代偿反应来激活 FGF8 信号传导。 | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
一种 p38 MAPK 抑制剂,可改变 MAPK 通路,从而可能以激活 FGF8 信号的方式改变细胞环境。 | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
作为 MAPK 通路一部分的 JNK 抑制剂;这种应激反应通路的改变可能会激活 FGF8 信号。 | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK 抑制剂可影响细胞骨架动力学,并可通过改变细胞结构激活 FGF8 信号。 | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
MEK 抑制剂通过改变 MAPK 信号,可激活对 FGF8 的调节。 | ||||||
GSK 2334470 | 1227911-45-6 | sc-364501 sc-364501A | 10 mg 50 mg | $195.00 $1142.00 | 1 | |
PDK1 是 AKT 上游激酶的特异性抑制剂;通过改变 AKT 信号,它可以激活 FGF8 信号。 |