Date published: 2025-10-15

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Lansoprazole Sulfide (CAS 103577-40-8)

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Alternate Names:
AG 1777; H 225/18; K 1252
Application:
Lansoprazole Sulfide is a metabolite of Lansoprazole
CAS Number:
103577-40-8
Molecular Weight:
353.36
Molecular Formula:
C16H14F3N3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Lansoprazole sulfide is a chemical compound related to lansoprazole, a proton pump inhibitor (PPI). This sulfide analog is of particular importance in the study of chemical metabolism and enzyme-substrate interactions. In biochemical research, it is used to investigate the metabolic pathways of lansoprazole, providing insights into the role of sulfur-containing metabolites. Researchers are interested in how lansoprazole sulfide interacts with cytochrome P450 enzymes, which are critical in the metabolism of many compounds. Understanding these interactions can shed light on possible metabolic products and their properties, which is essential for design and safety evaluation of bioactive compounds. Moreover, lansoprazole sulfide serves as a tool in mechanistic studies to map out the disposition and elimination of related compounds. Its behavior in biological systems can also help clarify the influence of sulfur atoms on the activity of PPIs.


Lansoprazole Sulfide (CAS 103577-40-8) References

  1. Stability and drug metabolism assessed by electrochemical methods.  |  Alvarez-Lueje, A. and Bollo, S. 2010. Comb Chem High Throughput Screen. 13: 712-27. PMID: 20429868
  2. Identification and validation of novel drug targets in Mycobacterium tuberculosis.  |  Singh, V. and Mizrahi, V. 2017. Drug Discov Today. 22: 503-509. PMID: 27649943
  3. Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.  |  Mdanda, S., et al. 2017. Biomed Chromatogr. 31: PMID: 28623874
  4. Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing.  |  Subtil, FT., et al. 2018. Int J Antimicrob Agents. 51: 378-384. PMID: 28843821
  5. Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.  |  Bown, L., et al. 2018. J Membr Biol. 251: 105-117. PMID: 29098330
  6. Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis.  |  Foo, CS., et al. 2018. mBio. 9: PMID: 30301850
  7. New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis.  |  Lupien, A., et al. 2020. PLoS Pathog. 16: e1008270. PMID: 31971990
  8. Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus.  |  Adeniji, AA., et al. 2020. Appl Microbiol Biotechnol. 104: 5633-5662. PMID: 32372202
  9. Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?  |  Bajeli, S., et al. 2020. Front Cell Infect Microbiol. 10: 589318. PMID: 33330134
  10. Prediction of QcrB Inhibition as a Measure of Antitubercular Activity with Machine Learning Protocols.  |  Khan, AA., et al. 2022. ACS Omega. 7: 18094-18102. PMID: 35664614
  11. Biocatalysis: A smart and green tool for the preparation of chiral drugs.  |  Rossino, G., et al. 2022. Chirality. 34: 1403-1418. PMID: 35929567
  12. Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase.  |  Beebe, J., et al. 2022. J Med Chem. 65: 13681-13691. PMID: 36257066
  13. Identification of the human P450 enzymes involved in lansoprazole metabolism.  |  Pearce, RE., et al. 1996. J Pharmacol Exp Ther. 277: 805-16. PMID: 8627562

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Lansoprazole Sulfide, 250 mg

sc-207820
250 mg
$311.00