Cardiotin Antibody (SR-2): sc-53002

Cardiotin Antibody (SR-2) is a mouse monoclonal IgM antibody that detects Cardiotin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Cardiotin antibody (SR-2) is available in a non-conjugated form, specifically designed for Cardiotin detection. Cardiotin is a high molecular weight protein complex predominantly located in the mitochondrial membrane, where Cardiotin plays a crucial role in maintaining mitochondrial function and cellular energy metabolism. Cardiotin′s structure consists of two subunits that share a highly conserved N-terminal 14 amino acid sequence, exhibiting significant homology to human skeletal muscle α-actinin. This structural similarity suggests Cardiotin forms a tetrameric transmembrane complex, with its N-terminus oriented towards the cytoplasm, allowing Cardiotin to interact effectively with actin filaments. Such interactions are vital for the structural integrity and functionality of cardiomyocytes, particularly during cardiac contractile dysfunction, where Cardiotin distribution can be disrupted in pathological conditions like chronic ischemic myocardium. Cardiotin (SR-2) monoclonal antibody serves as a valuable tool in immunohistochemistry for assessing mitochondrial activity disturbances in cardiomyocytes, providing insights into conditions such as chronic ischemia or chronic atrial fibrillation.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cardiotin Antibody (SR-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cardiotin Antibody (SR-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cardiotin Antibody (SR-2) Specifications

Alternate Product Name: Cardiotin complex

Product Clone Name: SR-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: 100 kDa Cardiotin subunit

Epitope Species: human

Product Reactivity/Detection: Cardiotin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cardiotin Antibody (SR-2): N/A

The preferred Cardiotin antibody is Cardiotin Antibody (R2G): sc-53001.