Molecular structure of Kahweol acetate, CAS Number: 81760-47-6
Kahweol acetate (CAS 81760-47-6)
See product citations (3)
Application:
Kahweol acetate is an inducer of glutathione S-transferase (GST)
CAS Number:
81760-47-6
Purity:
≥98%
Molecular Weight:
356.47
Molecular Formula:
C22H28O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kahweol acetate is an inducer of glutathione S-transferase. Kahweol acetate is a diterpene (a type of hydrocarbon) molecule found in the beans of Coffea arabica. It is structurally similar to cafestol. Unlike cafestol, also a diterpene from coffee, kahweol is somewhat difficult to isolate chemically, and therefore studies on it have been difficult to perform. The two are actually chemically quite similar, but their differences may be important.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Kahweol acetate (CAS 81760-47-6) References
- Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. | Kim, JY., et al. 2004. FEBS Lett. 569: 321-6. PMID: 15225655
- Inhibitory effect of the saponins derived from roots of Platycodon grandiflorum on carrageenan-induced inflammation. | Kim, JY., et al. 2006. Biosci Biotechnol Biochem. 70: 858-64. PMID: 16636452
- Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. | Niture, SK., et al. 2007. Carcinogenesis. 28: 378-89. PMID: 16950796
- The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells. | Kim, HG., et al. 2006. Toxicol Appl Pharmacol. 217: 332-41. PMID: 17097123
- Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. | Lee, KJ. and Jeong, HG. 2007. Toxicol Lett. 173: 80-7. PMID: 17689207
- Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells. | Kim, HG., et al. 2009. Toxicol Lett. 187: 28-34. PMID: 19429240
- Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells. | Iwamoto, H., et al. 2019. Prostate. 79: 468-479. PMID: 30569541
- Suppression of PMA-induced human fibrosarcoma HT-1080 invasion and metastasis by kahweol via inhibiting Akt/JNK1/2/p38 MAPK signal pathway and NF-κB dependent transcriptional activities. | Choi, JH., et al. 2019. Food Chem Toxicol. 125: 1-9. PMID: 30590137
- Suppressive Role of Androgen/Androgen Receptor Signaling via Chemokines on Prostate Cancer Cells. | Izumi, K. and Mizokami, A. 2019. J Clin Med. 8: PMID: 30871130
- Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells. | Makino, T., et al. 2021. Sci Rep. 11: 675. PMID: 33436830
- Kahweol, a Diterpenoid Molecule, Inhibits CTGF-Dependent Synthetic Phenotype Switching and Migration in Vascular Smooth Muscle Cells. | Lee, JH., et al. 2021. Molecules. 26: PMID: 33530626
- Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice. | Lam, LK., et al. 1987. J Med Chem. 30: 1399-403. PMID: 3612687
- Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer. | Eldesouki, S., et al. 2022. Molecules. 27: PMID: 36364160
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kahweol acetate, 10 mg | sc-228383 | 10 mg | $292.00 | |||
Kahweol acetate, 25 mg | sc-228383A | 25 mg | $355.00 |