Date published: 2025-11-3

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Zinc chloride (CAS 7646-85-7)

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Alternate Names:
Dichlorozinc
Application:
Zinc chloride is a lewis acid used to catalyze the Fischer Indole synthesis an the Friedel-Crafts acylation reactions
CAS Number:
7646-85-7
Purity:
≥97%
Molecular Weight:
136.30
Molecular Formula:
ZnCl2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Zinc chloride (ZnCl2) plays a crucial role in scientific research due to its versatile properties and diverse applications across various fields. One of its primary mechanisms of action lies in its role as a Lewis acid catalyst. Zinc chloride′s ability to accept electron pairs from other molecules makes it invaluable in catalyzing a wide range of organic transformations. In organic synthesis, zinc chloride facilitates reactions such as Friedel-Crafts acylations, alkylations, and rearrangements by activating electrophilic substrates and stabilizing reaction intermediates. Moreover, zinc chloride finds extensive use in the field of materials science, where it serves as a key component in the synthesis of zinc-containing materials and nanocomposites. Its ability to form stable coordination complexes with organic ligands enables the preparation of functionalized nanoparticles and hybrid materials with tailored properties for applications in catalysis, sensing, and energy storage. Additionally, research efforts have explored its potential in electrochemistry, where it is utilized as an electrolyte in batteries and electrochemical cells. Furthermore, zinc chloride is employed in analytical chemistry as a reagent for the determination and quantification of certain analytes. Its reaction with specific functional groups, such as alcohols and amines, enables their derivatization and subsequent analysis via chromatographic or spectroscopic techniques. Overall, zinc chloride continues to be a versatile and indispensable tool in scientific investigations, owing to its diverse functionalities and broad utility in research applications spanning organic synthesis, materials science, electrochemistry, and analytical chemistry.


Zinc chloride (CAS 7646-85-7) References

  1. Zinc inhibition of cAMP signaling.  |  Klein, C., et al. 2002. J Biol Chem. 277: 11859-65. PMID: 11805091
  2. The chemistry of amine-azide interconversion: catalytic diazotransfer and regioselective azide reduction.  |  Nyffeler, PT., et al. 2002. J Am Chem Soc. 124: 10773-8. PMID: 12207533
  3. Zinc Chloride and Lead Acetate-Induced Passive Avoidance Memory Retention Deficits Reversed by Nicotine and Bucladesine in Mice.  |  Tabrizian, K., et al. 2016. Biol Trace Elem Res. 169: 106-13. PMID: 26066527
  4. Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.  |  Steinritz, D., et al. 2018. Toxicol Lett. 293: 133-139. PMID: 28919489
  5. Additive Effects of Zinc Chloride on the Suppression of Hepatitis A Virus Replication by Interferon in Human Hepatoma Huh7 Cells.  |  Kanda, T., et al. 2020. In Vivo. 34: 3301-3308. PMID: 33144437
  6. Zinc chloride inhibits lysine decarboxylase production from Eikenella corrodens in vitro and its therapeutic implications.  |  Levine, M., et al. 2021. J Dent. 104: 103533. PMID: 33189800
  7. Zinc chloride affects chondrogenesis via VEGF signaling.  |  Hozain, S., et al. 2021. Exp Cell Res. 399: 112436. PMID: 33358860
  8. Zinc Chloride Enhances the Antioxidant Status, Improving the Functional and Structural Organic Disturbances in Streptozotocin-Induced Diabetes in Rats.  |  Anton, IC., et al. 2022. Medicina (Kaunas). 58: PMID: 36363577
  9. Effects of zinc chloride on boar sperm quality during liquid storage at 17°C.  |  Hu, Q. 2023. Vet Med Sci. 9: 1217-1225. PMID: 36757104
  10. Zinc chloride is effective as an antibiotic in biofilm prevention following septoplasty.  |  Noach, N., et al. 2023. Sci Rep. 13: 8344. PMID: 37221180

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Zinc chloride, 5 g

sc-203417
5 g
$20.00

Zinc chloride, 100 g

sc-203417A
100 g
$32.00

Zinc chloride, 500 g

sc-203417B
500 g
$87.00

Zinc chloride, 4 kg

sc-203417C
4 kg
$253.00