Molecular structure of Yangonin, CAS Number: 500-62-9
Yangonin (CAS 500-62-9)
See product citations (1)
Alternate Names:
4-Methoxy-6-(β-(p-anisyl)vinyl)-α-pyrone
Application:
Yangonin is one of the major components of kava extract
CAS Number:
500-62-9
Molecular Weight:
258.27
Molecular Formula:
C15H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Yangonin is a compound that has captured the interest of researchers due to it being found in the bark of the Kava plant. It is notable in research for its interactions with various neurotransmitter systems within the central nervous system. Studies involving Yangonin are focused on understanding its affinity for the GABAergic system and its influence on the cannabinoid receptors, particularly CB1. Research efforts are directed toward elucidating the chemical kinetics of Yangonin, as well as its potential modulatory effects on cognition. Additionally, Yangonin is investigated for its impact on neurochemical pathways and the molecular mechanisms underlying its activity.
Yangonin (CAS 500-62-9) References
- Interaction of various Piper methysticum cultivars with CNS receptors in vitro. | Dinh, LD., et al. 2001. Planta Med. 67: 306-11. PMID: 11458444
- Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. | Zou, L., et al. 2004. Phytomedicine. 11: 285-94. PMID: 15185840
- Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. | He, XG., et al. 1997. Planta Med. 63: 70-4. PMID: 17252331
- Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB₁ receptor ligand. | Ligresti, A., et al. 2012. Pharmacol Res. 66: 163-9. PMID: 22525682
- Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity. | Kong, Y., et al. 2018. Eur J Pharmacol. 824: 64-71. PMID: 29427579
- Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro. | Gao, X., et al. 2018. Toxicol Appl Pharmacol. 348: 105-116. PMID: 29660435
- Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor. | Dong, R., et al. 2019. Phytomedicine. 53: 134-142. PMID: 30668392
- Yangonin protects against estrogen-induced cholestasis in a farnesoid X receptor-dependent manner. | Dong, R., et al. 2019. Eur J Pharmacol. 857: 172461. PMID: 31220436
- Rapid detection and validated quantification of psychoactive compounds in complex plant matrices by direct analysis in real time-high resolution mass spectrometry - Application to 'Kava' psychoactive pepper products. | Chambers, MI., et al. 2019. Rapid Commun Mass Spectrom. 33: 1915-1925. PMID: 31323704
- Monoamine Oxidase Inhibition by Kavalactones from Kava (Piper Methysticum). | Prinsloo, D., et al. 2019. Planta Med. 85: 1136-1142. PMID: 31539917
- Kava constituents exert selective anticancer effects in oral squamous cell carcinoma cells in vitro. | Celentano, A., et al. 2020. Sci Rep. 10: 15904. PMID: 32985597
- Yangonin inhibits ethanol-induced hepatocyte senescence via miR-194/FXR axis. | Dong, R., et al. 2021. Eur J Pharmacol. 890: 173653. PMID: 33068587
- Yangonin treats inflammatory osteoporosis by inhibiting the secretion of inflammatory factors and RANKL expression. | Lu, F., et al. 2022. Inflammopharmacology. 30: 1445-1458. PMID: 35451724
Inhibitor of:
NF kappa B.Activator of:
CB1, and CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Yangonin, 5 mg | sc-205889 | 5 mg | $268.00 | |||
Yangonin, 10 mg | sc-205889A | 10 mg | $510.00 |