Molecular structure of Xanthorrhizol, CAS Number: 30199-26-9
Xanthorrhizol (CAS 30199-26-9)
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Alternate Names:
1,3,5,10-Bisabolatetraen-2-ol
Application:
Xanthorrhizol is a pro-apoptotic inhibitor of Cox-2 and NOS2
CAS Number:
30199-26-9
Purity:
≥95%
Molecular Weight:
218.33
Molecular Formula:
C15H22O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xanthorrhizol is a compound that has interest in several research domains due to its biological activities observed in laboratory applications. It is studied for its potential antioxidant properties, with researchers investigating into the mechanisms by which it can scavenge free radicals. In addition, Xanthorrhizol is investigated for its possible role in inhibiting the growth of various microorganisms, thereby contributing to the understanding of natural antimicrobial compounds. Researchers also explore its impact on certain enzymes and signaling pathways to elucidate its mode of action at the molecular level. Furthermore, Xanthorrhizol is a subject of interest in the study of natural products′ chemistry, where its structure-activity relationship is examined to comprehend how its chemical configuration affects its interaction with other molecules.
Xanthorrhizol (CAS 30199-26-9) References
- Effect of xanthorrhizol, xanthorrhizol glycoside and trachylobanoic acid isolated from Cachani complex plants upon the contractile activity of uterine smooth muscle. | Ponce-Monter, H., et al. 1999. Phytother Res. 13: 202-5. PMID: 10353157
- Xanthorrhizol: a potential antibacterial agent from Curcuma xanthorrhiza against Streptococcus mutans. | Hwang, JK., et al. 2000. Planta Med. 66: 196-7. PMID: 10763606
- Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells. | Ismail, N., et al. 2005. Anticancer Res. 25: 2221-7. PMID: 16158967
- Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. | Chung, WY., et al. 2007. Carcinogenesis. 28: 1224-31. PMID: 17234720
- Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells. | Handayani, T., et al. 2007. Anticancer Res. 27: 965-71. PMID: 17465228
- Xanthorrhizol induced DNA fragmentation in HepG2 cells involving Bcl-2 family proteins. | Tee, TT., et al. 2012. Biochem Biophys Res Commun. 420: 834-8. PMID: 22465013
- Xanthorrhizol induces apoptosis through ROS-mediated MAPK activation in human oral squamous cell carcinoma cells and inhibits DMBA-induced oral carcinogenesis in hamsters. | Kim, JY., et al. 2013. Phytother Res. 27: 493-8. PMID: 22627996
- Quantitative determination of xanthorrhizol in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study. | Choi, S., et al. 2017. J Pharm Biomed Anal. 132: 56-59. PMID: 27693953
- Synergistic Impact of Xanthorrhizol and d-Δ-Tocotrienol on the Proliferation of Murine B16 Melanoma Cells and Human DU145 Prostate Carcinoma Cells. | Chan, D., et al. 2021. Nutr Cancer. 73: 1746-1757. PMID: 32811212
- The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli. | Yogiara, ., et al. 2020. Bioorg Med Chem Lett. 30: 127651. PMID: 33130290
- Xanthorrhizol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Modulating Akt/eNOS Signaling and the NF-[Formula: see text]B-Dependent Expression of Cell Adhesion Molecules. | Lee, SK., et al. 2021. Am J Chin Med. 49: 737-751. PMID: 33683188
- Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review. | Khalid, GS., et al. 2021. Drug Des Devel Ther. 15: 1149-1156. PMID: 33731986
- Xanthorrhizol inhibits non-small cell carcinoma (A549) cell growth and promotes apoptosis through modulation of PI3K/AKT and NF-κB signaling pathway. | Cai, Y., et al. 2022. Environ Toxicol. 37: 120-130. PMID: 34664399
- Xanthorrhizol Ameliorates Oxidative Stress and Inflammation in Freund's Complete Adjuvant-Induced Rheumatoid Arthritis in Rats. | Zhou, M., et al. 2022. Appl Biochem Biotechnol. 194: 6423-6437. PMID: 35932370
- Bioavailability of xanthorrhizol following oral administration of a supercritical extract of Java turmeric. | Kang, J., et al. 2022. Food Sci Biotechnol. 31: 1309-1313. PMID: 35992318
Inhibitor of:
Cox, Cox-2, and NOS2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xanthorrhizol, 1 mg | sc-202855 | 1 mg | $194.00 |