Molecular structure of WWL70, CAS Number: 947669-91-2
WWL70 (CAS 947669-91-2)
Alternate Names:
N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4′-(aminocarbonyl)[1,1′-biphenyl]-4-yl carbamic acid ester
Application:
WWL70 is a selective inhibitor of ABHD6
CAS Number:
947669-91-2
Molecular Weight:
437.49
Molecular Formula:
C27H23N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A selective inhibitor of α/β-Hydrolase domain 6.1
WWL70 (CAS 947669-91-2) References
- A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. | Li, W., et al. 2007. J Am Chem Soc. 129: 9594-5. PMID: 17629278
- Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. | Straiker, A., et al. 2009. Mol Pharmacol. 76: 1220-7. PMID: 19767452
- Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. | Tchantchou, F. and Zhang, Y. 2013. J Neurotrauma. 30: 565-79. PMID: 23151067
- Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. | Alhouayek, M., et al. 2013. Proc Natl Acad Sci U S A. 110: 17558-63. PMID: 24101490
- Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis. | Wen, J., et al. 2015. Neuropharmacology. 99: 196-209. PMID: 26189763
- α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. | Zhao, S., et al. 2016. Cell Rep. 14: 2872-88. PMID: 26997277
- Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. | Pinheiro, BS., et al. 2016. Brain Res Bull. 124: 222-30. PMID: 27208730
- WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism. | Tanaka, M., et al. 2017. J Neuroinflammation. 14: 7. PMID: 28086912
- WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms. | Wen, J., et al. 2018. J Neuroinflammation. 15: 9. PMID: 29310667
- Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the Pentylenetetrazol induced tonic- clonic seizures. | Zareie, P., et al. 2018. Metab Brain Dis. 33: 939-948. PMID: 29504066
- Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis. | Manterola, A., et al. 2018. Neuropharmacology. 141: 181-191. PMID: 30171986
- The α/β-hydrolase domain 6 inhibitor WWL70 decreases endotoxin-induced lung inflammation in mice, potential contribution of 2-arachidonoylglycerol, and lysoglycerophospholipids. | Bottemanne, P., et al. 2019. FASEB J. 33: 7635-7646. PMID: 30896979
- Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells. | Szeremeta, J., et al. 2019. Prostaglandins Other Lipid Mediat. 142: 59-67. PMID: 30978461
Inhibitor of:
ABHD6, Enzyme, and Monoglyceride Lipase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WWL70, 1 mg | sc-222420 | 1 mg | $54.00 | |||
WWL70, 5 mg | sc-222420A | 5 mg | $105.00 |