Molecular structure of Usnic acid, CAS Number: 125-46-2
Usnic acid (CAS 125-46-2)
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Alternate Names:
Uanic acid; Usninic acid; Usnein
Application:
Usnic acid is an enzyme inhibiting antitumor agent
CAS Number:
125-46-2
Purity:
≥98%
Molecular Weight:
344.32
Molecular Formula:
C18H16O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Usnic acid, a naturally occurring secondary metabolite found in lichens. This compound, derived from the symbiotic relationship between fungi and algae, possesses remarkable antibacterial, antifungal, and antiviral properties. The extensive scientific studies conducted on usnic acid have focused on elucidating its mechanism of action. It is hypothesized that usnic acid hampers the growth of bacteria, fungi, and viruses by disrupting their cell walls.
Usnic acid (CAS 125-46-2) References
- Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress. | Han, D., et al. 2004. Biochem Pharmacol. 67: 439-51. PMID: 15037196
- Usnic acid causes apoptotic-like death in Leishmania major, L. infantum and L. tropica. | Derici, MK., et al. 2018. 3 Biotech. 8: 384. PMID: 30148034
- Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and γ-H2A.X phosphorylation. | Kumar, K., et al. 2020. Chem Biol Interact. 315: 108898. PMID: 31715134
- Anticholinergic and antioxidant activities of usnic acid-an activity-structure insight. | Cetin Cakmak, K. and Gülçin, İ. 2019. Toxicol Rep. 6: 1273-1280. PMID: 31832335
- Usnic acid as calcium ionophore and mast cells stimulator. | Chelombitko, MA., et al. 2020. Biochim Biophys Acta Biomembr. 1862: 183303. PMID: 32251647
- Derivatives of usnic acid cause cytostatic effect in Caco-2 cells. | Samuelsen, L., et al. 2021. Nat Prod Res. 35: 4953-4959. PMID: 32352327
- Curcumin/Usnic Acid-Loaded Electrospun Nanofibers Based on Hyaluronic Acid. | Snetkov, P., et al. 2020. Materials (Basel). 13: PMID: 32784533
- Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity. | Sun, TX., et al. 2021. Phytother Res. 35: 3916-3935. PMID: 33970512
- Potential of Usnic Acid Compound from Lichen Genus Usnea sp. as Antidiabetic Agents. | Maulidiyah, M., et al. 2022. J Oleo Sci. 71: 127-134. PMID: 35013035
- Usnic acid induced changes in biomolecules and their association with apoptosis in squamous carcinoma (A-431) cells: A flow cytometry, FTIR and DLS spectroscopic study. | Kumari, M., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 274: 121098. PMID: 35257985
- Usnic Acid Isolated from Usnea antarctica (Du Rietz) Reduced In Vitro Angiogenesis in VEGF- and bFGF-Stimulated HUVECs and Ex Ovo in Quail Chorioallantoic Membrane (CAM) Assay. | Petrová, K., et al. 2022. Life (Basel). 12: PMID: 36143480
- Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in Caenorhabditis elegans. | Xiao, Y., et al. 2022. iScience. 25: 105539. PMID: 36425761
- Unraveling usnic acid: a comparison of biosynthetic gene clusters between two reindeer lichen (Cladonia rangiferina and C. uncialis). | Egbert, S., et al. 2022. Fungal Biol. 126: 697-706. PMID: 36517138
- Usnic Acid-Mediated Exchange of Protons for Divalent Metal Cations across Lipid Membranes: Relevance to Mitochondrial Uncoupling. | Rokitskaya, TI., et al. 2022. Int J Mol Sci. 23: PMID: 36555847
- Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria. | Abo-Khatwa, AN., et al. 1996. Nat Toxins. 4: 96-102. PMID: 8726330
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Usnic acid, 5 g | sc-204936 | 5 g | $78.00 | |||
Usnic acid, 25 g | sc-204936A | 25 g | $282.00 |